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Verfasst von:Haas, Maximilian [VerfasserIn]   i
 Kriegmair, Maximilian [VerfasserIn]   i
 Breyer, Johannes [VerfasserIn]   i
 Sikic, Danijel [VerfasserIn]   i
 Wezel, Felix [VerfasserIn]   i
 Roghmann, Florian [VerfasserIn]   i
 Brehmer, Mirco [VerfasserIn]   i
 Wirtz, Ralph M. [VerfasserIn]   i
 Jarczyk, Jonas [VerfasserIn]   i
 Erben, Philipp [VerfasserIn]   i
 Bahlinger, Veronika [VerfasserIn]   i
 Goldschmidt, Franziska [VerfasserIn]   i
 Fechner, Guido [VerfasserIn]   i
 Chen, Jack [VerfasserIn]   i
 Paxinos, Ellen [VerfasserIn]   i
 Bates, Michael [VerfasserIn]   i
 Zengerling, Friedemann [VerfasserIn]   i
 Bolenz, Christian [VerfasserIn]   i
 Burger, Maximilian [VerfasserIn]   i
 Hartmann, Arndt [VerfasserIn]   i
 Eckstein, Markus [VerfasserIn]   i
Titel:Improving detection of carcinoma in situ in bladder cancer: urinary cytology vs the Xpert BC Monitor
Verf.angabe:Maximilian Haas, Maximilian C. Kriegmair, Johannes Breyer, Danijel Sikic, Felix Wezel, Florian Roghmann, Mirco Brehmer, Ralph M. Wirtz, Jonas Jarczyk, Philipp Erben, Veronika Bahlinger, Franziska Goldschmidt, Guido Fechner, Jack Chen, Ellen Paxinos, Michael Bates, Friedemann Zengerling, Christian Bolenz, Maximilian Burger, Arndt Hartmann and Markus Eckstein
E-Jahr:2024
Jahr:November 2024
Umfang:8 S.
Fussnoten:Erstmals veröffenticht: 08. Mai 2024 ; Gesehen am 10.12.2024
Titel Quelle:Enthalten in: BJU international
Ort Quelle:Oxford : Wiley-Blackwell, 1999
Jahr Quelle:2024
Band/Heft Quelle:134(2024), 5 vom: Nov., Seite 755-762
ISSN Quelle:1464-410X
Abstract:Objective To investigate and compare the performance of urinary cytology and the Xpert BC Monitor test in the detection of bladder cancer in various clinically significant patient cohorts, including patients with carcinoma in situ (CIS), in a prospective multicentre setting, aiming to identify potential applications in clinical practice. Patients and Methods A total of 756 patients scheduled for transurethral resection of bladder tumour (TURBT) were prospectively screened between July 2018 and December 2020 at six German University Centres. Central urinary cytology and Xpert BC Monitor tests were performed prior to TURBT. The diagnostic performance of urinary cytology and the Xpert BC Monitor was evaluated according to sensitivity (SN), specificity (SC), negative predictive value (NPV) and positive predictive value (PPV). Statistical comparison of urinary cytology and the Xpert BC Monitor was conducted using the McNemar test. Results Of 756 screened patients, 733 (568 male [78%]; median [interquartile range] age 72?[62?79] years) were included. Bladder cancer was present in 482 patients (65.8%) with 258 (53.5%) high-grade tumours. Overall SN, SC, NPV and PPV were 39%, 93%, 44% and 92% for urinary cytology, and 75%, 69%, 59% and 82% for the Xpert BC Monitor. In patients with CIS (concomitant or solitary), SN, SC, NPV and PPV were 59%, 93%, 87% and 50% for urinary cytology, and 90%, 69%, 95% and 50% for the Xpert BC Monitor. The Xpert BC Monitor missed four tumours (NPV?=?98%) in patients with solitary CIS, while potentially avoiding 63.3% of TURBTs in inconclusive or negative cystoscopy and a negative Xpert result. Conclusion Positive urinary cytology may indicate bladder cancer and should be taken seriously. The Xpert BC Monitor may represent a useful diagnostic tool for correctly identifying patients with solitary CIS and unsuspicious or inconclusive cystoscopy.
DOI:doi:10.1111/bju.16389
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1111/bju.16389
 kostenfrei: Volltext: http://bjui.journals.onlinelibrary.wiley.com/doi/10.1111/bju.16389
 DOI: https://doi.org/10.1111/bju.16389
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:bladder cancer
 carcinoma in situ
 cytology
 NMIBC
 urine marker
 Xpert
K10plus-PPN:1911762443
Verknüpfungen:→ Zeitschrift

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