| |  Online-Ressource |
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| Verfasst von: | Ponsel, Simon [VerfasserIn]  |
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| | Zhang, Jiaojiao [VerfasserIn] |
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| | Pilz, Maximilian [VerfasserIn] |
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| | Yanovsky, Yevgenij [VerfasserIn] |
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| | Brankačk, Jurij [VerfasserIn] |
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| | Draguhn, Andreas [VerfasserIn] |
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| Titel: | Alterations of distributed neuronal network oscillations during acute pain in freely-moving mice |
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| Verf.angabe: | Simon Ponsel, Jiaojiao Zhang, Maximilian Pilz, Yevgenij Yanovsky, Jurij Brankačk, Andreas Draguhn |
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| E-Jahr: | 2020 |
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| Jahr: | 11 August 2020 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 11. August 2020, Artikelversion: 6. September 2020 ; Gesehen am 10.12.2024 |
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| Titel Quelle: | Enthalten in: IBRO reports |
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| Ort Quelle: | Amsterdam : Elsevier, 2016 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 9(2020) vom: Dez., Seite 195-206 |
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| ISSN Quelle: | 2451-8301 |
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| Abstract: | The experience of pain involves the activation of multiple brain areas. Pain-specific activity patterns within and between these local networks remain, however, largely unknown. We measured neuronal network oscillations in different relevant regions of the mouse brain during acute pain, induced by subcutaneous injection of capsaicin into the left hind paw. Field potentials were recorded from primary somatosensory cortex, anterior cingulate cortex (ACC), posterior insula, ventral posterolateral thalamic nucleus, parietal cortex, central nucleus of the amygdala and olfactory bulb. Analysis included power spectra of local signals as well as interregional coherences and cross-frequency coupling (CFC). Capsaicin injection caused hypersensitivity to mechanical stimuli for at least one hour. At the same time, CFC between low (1−12Hz) and fast frequencies (80−120Hz) was increased in the ACC, as well as interregional coherence of low frequency oscillations (< 30Hz) between several networks. However, these changes were not significant anymore after multiple comparison corrections. Using a variable selection method (elastic net) and a logistic regression classifier, however, the pain state was reliably predicted by combining parameters of power and coherence from various regions. Distinction between capsaicin and saline injection was also possible when data were restricted to frequencies <30Hz, as used in clinical electroencephalography (EEG). Our findings indicate that changes of distributed brain oscillations may provide a functional signature of acute pain or pain-related alterations in activity. |
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| DOI: | doi:10.1016/j.ibror.2020.08.001 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.ibror.2020.08.001 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2451830120300340 |
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| | DOI: https://doi.org/10.1016/j.ibror.2020.08.001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Acute and tonic pain |
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| | Brain oscillations |
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| | Capsaicin |
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| | Cross-frequency coupling |
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| | Elastic net |
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| | Freely moving mouse |
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| | Interregional coherence |
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| | Local field potential |
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| | Logistic regression classifier |
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| | Power spectral density |
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| K10plus-PPN: | 191178174X |
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| Verknüpfungen: | → Zeitschrift |
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Alterations of distributed neuronal network oscillations during acute pain in freely-moving mice / Ponsel, Simon [VerfasserIn]; 11 August 2020 (Online-Ressource)
