| |  Online-Ressource |
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| Verfasst von: | Konnerth, Dinah [VerfasserIn]  |
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| | Gaasch, Aurelie [VerfasserIn] |
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| | Zinn, Annemarie [VerfasserIn] |
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| | Rogowski, Paul [VerfasserIn] |
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| | Rottler, Maya [VerfasserIn] |
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| | Walter, Franziska [VerfasserIn] |
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| | Knoth, Johannes [VerfasserIn] |
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| | Sturdza, Alina [VerfasserIn] |
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| | Oelmann, Jan [VerfasserIn] |
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| | Grawe, Freba [VerfasserIn] |
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| | Bodensohn, Raphael [VerfasserIn] |
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| | Belka, Claus [VerfasserIn] |
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| | Corradini, Stefanie [VerfasserIn] |
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| Titel: | Hematologic toxicity and bone marrow-sparing strategies in chemoradiation for locally advanced cervical cancer |
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| Titelzusatz: | A Systematic Review |
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| Verf.angabe: | Dinah Konnerth, Aurelie Gaasch, Annemarie Zinn, Paul Rogowski, Maya Rottler, Franziska Walter, Johannes Knoth, Alina Sturdza, Jan Oelmann, Freba Grawe, Raphael Bodensohn, Claus Belka and Stefanie Corradini |
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| E-Jahr: | 2024 |
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| Jahr: | 11 Mai 2024 |
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| Umfang: | 21 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 11.12.2024 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 16(2024), 10, Artikel-ID 1842, Seite 1-21 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | The standard treatment for locally advanced cervical cancer typically includes concomitant chemoradiation, a regimen known to induce severe hematologic toxicity (HT). Particularly, pelvic bone marrow dose exposure has been identified as a contributing factor to this hematologic toxicity. Chemotherapy further increases bone marrow suppression, often necessitating treatment interruptions or dose reductions. A systematic search for original articles published between 1 January 2006 and 7 January 2024 that reported on chemoradiotherapy for locally advanced cervical cancer and hematologic toxicities was conducted. Twenty-four articles comprising 1539 patients were included in the final analysis. HT of grade 2 and higher was observed across all studies and frequently exceeded 50%. When correlating active pelvic bone marrow and HT, significant correlations were found for volumes between 10 and 45 Gy and HT of grade 3 and higher. Several dose recommendations for pelvic bone and pelvic bone marrow sparing to reduce HT were established, including V10 < 90-95%, V20 < 65-86.6% and V40 < 22.8-40%. Applying dose constraints to the pelvic bone/bone marrow is a promising approach for reducing HT, and thus reliable implementation of therapy. However, prospective randomized controlled trials are needed to define precise dose constraints and optimize clinical strategies. |
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| DOI: | doi:10.3390/cancers16101842 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers16101842 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/16/10/1842 |
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| | DOI: https://doi.org/10.3390/cancers16101842 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | bone marrow |
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| | cervical cancer |
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| | chemoradiotherapy |
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| | dose constraints |
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| | hematologic toxicity |
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| K10plus-PPN: | 1912018128 |
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| Verknüpfungen: | → Zeitschrift |
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Hematologic toxicity and bone marrow-sparing strategies in chemoradiation for locally advanced cervical cancer / Konnerth, Dinah [VerfasserIn]; 11 Mai 2024 (Online-Ressource)
