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Status: Bibliographieeintrag

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Verfasst von:Klank, David Karl [VerfasserIn]   i
 Löffler, Christian [VerfasserIn]   i
 Friedrich, Julian [VerfasserIn]   i
 Hoffmann, Martin [VerfasserIn]   i
 Paschka, Peter [VerfasserIn]   i
 Bergner, Raoul [VerfasserIn]   i
Titel:The urine Light Chain/eGFR quotient as a tool to rule out cast nephropathy in myeloma-associated kidney failure
Verf.angabe:David Klank, Christian Löffler, Julian Friedrich, Martin Hoffmann, Peter Paschka and Raoul Bergner
E-Jahr:2024
Jahr:8 May 2024
Umfang:10 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 11.12.2024
Titel Quelle:Enthalten in: Biomedicines
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2024
Band/Heft Quelle:12(2024), 5, Artikel-ID 1032, Seite 1-10
ISSN Quelle:2227-9059
Abstract:Kidney involvement with resulting kidney failure leads to increased mortality in patients with multiple myeloma (MM). Cast nephropathy (CN), in particular, if left untreated, quickly leads to kidney failure requiring dialysis and has a very poor prognosis for the affected patient. The gold standard for diagnosing kidney involvement is a kidney biopsy. However, due to bleeding risk, this cannot be done in every patient. We recently reported that a quotient of urine light chain (LCurine) to glomerular filtration rate (eGFR) is a non-invasive diagnostic tool for patients with kidney involvement in MM. But this quotient has not yet been tested in everyday clinical practice. In this study, our LCurine/eGFR ratio was tested on 67 patients in two centers. Enrollment took place between January 2019 and September 2023. A total of 18 of the 67 patients had CN. With the threshold defined in our initial paper, we were able to show a sensitivity of 100% with a specificity of 85.7% for CN in patients with MM. As a result, the LCurine/eGFR quotient recognizes 100% of all CN and can therefore detect this group, which has a very poor prognosis, without the need for a kidney biopsy.
DOI:doi:10.3390/biomedicines12051032
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/biomedicines12051032
 kostenfrei: Volltext: https://www.mdpi.com/2227-9059/12/5/1032
 DOI: https://doi.org/10.3390/biomedicines12051032
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cast nephropathy
 kidney biopsy
 multiple myeloma
K10plus-PPN:1912025736
Verknüpfungen:→ Zeitschrift

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