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Status: Bibliographieeintrag

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Verfasst von:Amr, Ali [VerfasserIn]   i
 Kayvanpour, Elham [VerfasserIn]   i
 Reich, Christoph [VerfasserIn]   i
 Kölemen, Jan [VerfasserIn]   i
 Asokan, Shamily [VerfasserIn]   i
 Frey, Norbert [VerfasserIn]   i
 Meder, Benjamin [VerfasserIn]   i
 Sedaghat-Hamedani, Farbod [VerfasserIn]   i
Titel:Assessing the applicability of cardiac myosin inhibitors for hypertrophic cardiomyopathy management in a large single center cohort
Verf.angabe:Ali Amr, Elham Kayvanpour, Christoph Reich, Jan Koelemen, Shamily Asokan, Norbert Frey, Benjamin Meder, Farbod Sedaghat-Hamedani
E-Jahr:2024
Jahr:20 June 2024
Umfang:6 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 13.12.2024
Titel Quelle:Enthalten in: Reviews in cardiovascular medicine
Ort Quelle:New York, NY : MedReview LLC, 2000
Jahr Quelle:2024
Band/Heft Quelle:25(2024), 6, Artikel-ID 225, Seite 1-6
ISSN Quelle:2153-8174
Abstract:Background: Cardiac myosin inhibitors (CMIs), including Mavacamten and Aficamten, have emerged as a groundbreaking treatment for hypertrophic cardiomyopathy (HCM). The results from phase 2 and 3 randomized clinical trials for both drugs have showed promising outcomes. However, the highly selective patient recruitment for these trials raises questions about the generalizability of the observed positive effects across broader patient populations suffering from HCM. Methods: A retrospective cohort study at University Hospital Heidelberg included 404 HCM patients. Baseline assessments included family history, electrocardiograms (ECGs), and advanced cardiac imaging, to ensure the exclusion of secondary causes of left ventricular hypertrophy. Results: Among the HCM patients evaluated, only a small percentage met the inclusion criteria for recent CMI trials: 10.4% for EXPLORER-HCM and 4.7% for SEQUOIA-HCM. The predominant exclusion factor was the stringent left ventricular outflow tract (LVOT) gradient requirement. Conclusions: This study highlights a significant discrepancy between patient demographics in clinical trials and those encountered in routine HCM clinical practice. Despite promising results from the initial randomized clinical trials that led to the approval of Mavacamten, the selected patient population only represents a small part of the HCM patient cohort seen in routine clinics. This study advocates for further expanded randomized clinical trials with broader inclusion criteria to represent diverse primary HCM patient populations.
DOI:doi:10.31083/j.rcm2506225
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.31083/j.rcm2506225
 kostenfrei: Volltext: https://www.imrpress.com/journal/RCM/25/6/10.31083/j.rcm2506225
 DOI: https://doi.org/10.31083/j.rcm2506225
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1912217635
Verknüpfungen:→ Zeitschrift

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