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| Verfasst von: | Campana, Mattia [VerfasserIn]  |
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| | Schneider-Axmann, Thomas [VerfasserIn] |
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| | Wobrock, Thomas [VerfasserIn] |
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| | Malchow, Berend [VerfasserIn] |
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| | Langguth, Berthold [VerfasserIn] |
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| | Landgrebe, Michael [VerfasserIn] |
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| | Eichhammer, Peter [VerfasserIn] |
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| | Frank, Elmar [VerfasserIn] |
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| | Cordes, Joachim [VerfasserIn] |
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| | Wölwer, Wolfgang [VerfasserIn] |
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| | Gaebel, Wolfgang [VerfasserIn] |
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| | Winterer, Georg [VerfasserIn] |
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| | Hajak, Göran [VerfasserIn] |
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| | Ohmann, Christian [VerfasserIn] |
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| | Verde, Pablo Emilio [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| | Ahmed, Raees [VerfasserIn] |
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| | Mortazavi, Matin [VerfasserIn] |
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| | Strube, Wolfgang [VerfasserIn] |
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| | Falkai, Peter [VerfasserIn] |
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| | Hasan, Alkomiet [VerfasserIn] |
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| | Wagner, Elias Maximilian [VerfasserIn] |
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| Titel: | Assessing the impact of sex on high-frequency repetitive transcranial magnetic stimulation's clinical response in schizophrenia |
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| Titelzusatz: | results from a secondary analysis |
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| Verf.angabe: | Mattia Campana, Thomas Schneider-Axmann, Thomas Wobrock, Berend Malchow, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Joachim Cordes, Wolfgang Wölwer, Wolfgang Gaebel, Georg Winterer, Göran Hajak, Christian Ohmann, Pablo E. Verde, Marcella Rietschel, Raees Ahmed, Matin Mortazavi, Wolfgang Strube, Peter Falkai, Alkomiet Hasan & Elias Wagner |
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| E-Jahr: | 2024 |
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| Jahr: | [01 May 2024] |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 16.12.2024 |
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| Titel Quelle: | Enthalten in: The world journal of biological psychiatry |
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| Ort Quelle: | Abingdon : Taylor & Francis Group, 2000 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 25(2024), 4, Seite 233-241 |
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| ISSN Quelle: | 1814-1412 |
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| Abstract: | The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge. Subject´s sex critically influences rTMS' treatment outcomes. Females with major depressive disorder are more likely to respond to rTMS, while SCZ data is scarce. Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we assessed the impact of sex on rTMS´ clinical response rate from screening up to 105 days after intervention among SCZ patients. The impact of resting motor threshold (RMT) on response rates was also assessed. 157 patients received either active or sham rTMS treatment. No significant group differences were observed. Linear mixed model showed no effects on response rates (all p > 0.519). Apart from a significant sex*time interaction for the positive subscale of the positive and negative syndrome scale (PANSS) scores (p = 0.032), no other significant effects of sex on continuous PANSS scores were observed. RMT had no effect on response rate. In the largest rTMS trial on the treatment of SCZ negative symptoms we did not observe any significant effect of sex on treatment outcomes. Better assessments of sex-related differences could improve treatment individualisation. |
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| DOI: | doi:10.1080/15622975.2024.2327028 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1080/15622975.2024.2327028 |
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| | DOI: https://doi.org/10.1080/15622975.2024.2327028 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | negative symptoms |
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| | RESIS |
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| | rTMS |
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| | schizophrenia |
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| | sex |
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| K10plus-PPN: | 1912366622 |
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| Verknüpfungen: | → Zeitschrift |
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Assessing the impact of sex on high-frequency repetitive transcranial magnetic stimulation's clinical response in schizophrenia / Campana, Mattia [VerfasserIn]; [01 May 2024] (Online-Ressource)
