Status: Bibliographieeintrag
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| Verfasst von: | Beöthe, Tamás [VerfasserIn]  |
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| | Docs, Janos [VerfasserIn] |
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| | Kovacs, Gyula [VerfasserIn] |
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| | Peterfi, Lehel [VerfasserIn] |
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| Titel: | Increased level of TXNIP and nuclear translocation of TXN is associated with end stage renal disease and development of multiplex renal tumours |
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| Verf.angabe: | Tamas Beothe, Janos Docs, Gyula Kovacs and Lehel Peterfi |
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| E-Jahr: | 2024 |
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| Jahr: | 17 July 2024 |
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| Umfang: | 7 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 16.12.2024 |
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| Titel Quelle: | Enthalten in: BMC nephrology |
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| Ort Quelle: | London : BioMed Central, 2000 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 25(2024), Artikel-ID 227, Seite 1-7 |
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| ISSN Quelle: | 1471-2369 |
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| Abstract: | Background: End-stage and acquired cystic renal disease (ESRD/ACRD) kidneys are characterized by inflammatory remodelling and multiplex renal cell carcinomas (RCC). Eosinophilic vacuolated tumour (EVT) occurs exclusively in ACRD. The aim of this study was to identify the involvement of thioredoxin-interacting protein (TXNIP) and thioredoxin (TXN) in ESRD/ACRD pathology. Methods: Expression of TXNIP and TXN was examined in histological slides of 6 ESRD and 6 ACRD kidneys, precursor lesions and associated tumours as well as of RCCs from the general population by immunohistochemistry. Results: Strong TXNIP expression was seen in epithelial cells, myo-fibroblasts and endothelial cells and weak TXN expression in ESRD/ACRD kidneys and tumours. In ACRD specific EVT and its precursors TXN were translocated into nuclei. Conclusion: The impaired TXNIP/TXN redox homeostasis might be associated with development of multiplex cancer especially of EVT in ESRD/ACRD kidney. |
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| DOI: | doi:10.1186/s12882-024-03653-4 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s12882-024-03653-4 |
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| | DOI: https://doi.org/10.1186/s12882-024-03653-4 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer |
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| | End stage kidney |
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| | Immunohistochemistry |
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| | TXN |
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| | TXNIP |
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| K10plus-PPN: | 1912374226 |
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| Verknüpfungen: | → Zeitschrift |
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Increased level of TXNIP and nuclear translocation of TXN is associated with end stage renal disease and development of multiplex renal tumours / Beöthe, Tamás [VerfasserIn]; 17 July 2024 (Online-Ressource)
69284068
