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Status: Bibliographieeintrag

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Verfasst von:Meißner, Maria [VerfasserIn]   i
 Steinke, Eva [VerfasserIn]   i
 Wielpütz, Mark Oliver [VerfasserIn]   i
 Joachim, Cornelia [VerfasserIn]   i
 Sommerburg, Olaf [VerfasserIn]   i
 Mall, Marcus A. [VerfasserIn]   i
 Stahl, Mirjam [VerfasserIn]   i
Titel:Impact of reanalysis of nitrogen multiple-breath washout on its relationship with chest magnetic resonance imaging findings in clinically stable and pulmonary exacerbated children with cystic fibrosis
Verf.angabe:Maria Meißner, Eva Steinke, Mark Oliver Wielpuetz, Cornelia Joachim, Olaf Sommerburg, Marcus Alexander Mall, Mirjam Stahl
Jahr:2024
Umfang:10 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 18.12.2024 ; Online veröffentlicht: 18. Dezember 2023
Titel Quelle:Enthalten in: Klinische Pädiatrie
Ort Quelle:Stuttgart : Thieme, 1980
Jahr Quelle:2024
Band/Heft Quelle:236(2024), 2, Seite 106-115
ISSN Quelle:1439-3824
Abstract:Rationale Multiple-breath washout (MBW)-derived lung clearance index (LCI) detects lung disease in children with cystic fibrosis (CF). Correction of a cross-talk error in the software of the MBW device Exhalyzer D in a new software version has generated significant interest regarding its impact on previous MBW findings. Since LCI and chest magnetic resonance imaging (MRI) correlated before in CF children, this study aims to reassess previous MBW data after correction.Patients/Methods Reanalysis of the main findings from a previously published study comparing MBW and MRI in a pediatric CF cohort by reassessment of nitrogen (N-2) MBW of 61 stable children with CF, 75 age-matched healthy controls (HC), and 15 CF children with pulmonary exacerbation (PEx) in the corrected software version.Results The corrected LCI (N2LCIcor) decreased in the entire cohort (-17.0 (11.2)%), HC (-8.5 (8.2)%), stable CF children (-22.2 (11.1)%), and within the PEx group at baseline, at PEx and after antibiotic therapy (-21.5 (7.3)%; -22.5 (6.1)%; -21.4 (6.6)%; all P<0.01). N2LCIcor and N2LCIpre correlated with chest MRI scores in stable CF (r=0.70 to 0.84; all P<0.01) without a significant difference between N2LCIcor and N 2 LCI pre . Change in LCI from baseline to PEx and from PEx to after therapy decreased from N 2 LCI pre to N2LCIcor, but these changes remained significant (all P=0.001).Discussion/Conclusions Our results indicate that N2LCIcor is significantly lower than N2LCIpre, but key results published in the original study demonstrating N2MBW and MRI as complementary methods for clinical surveillance in children with CF remain unaffected.
DOI:doi:10.1055/a-2214-7217
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1055/a-2214-7217
 Volltext: https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2214-7217#info
 DOI: https://doi.org/10.1055/a-2214-7217
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cystic fibrosis
 lung clearance index
 lung disease
 LUNG-DISEASE
 magnetic resonance imaging
 multiple-breath washout
 noninvasive monitoring
 PROGRESSION
K10plus-PPN:1912931257
Verknüpfungen:→ Zeitschrift

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