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Verfasst von:Wucherpfennig, Lena [VerfasserIn]   i
 Wünnemann, Felix [VerfasserIn]   i
 Eichinger, Monika [VerfasserIn]   i
 Schmitt, Niclas [VerfasserIn]   i
 Seitz, Angelika [VerfasserIn]   i
 Baumann, Ingo [VerfasserIn]   i
 Roehmel, Jobst F. [VerfasserIn]   i
 Stahl, Mirjam [VerfasserIn]   i
 Hämmerling, Susanne Hedwig [VerfasserIn]   i
 Chung, Jaehi [VerfasserIn]   i
 Schenk, Jens-Peter [VerfasserIn]   i
 Alrajab, Abdulsattar [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Mall, Marcus A. [VerfasserIn]   i
 Wielpütz, Mark Oliver [VerfasserIn]   i
 Sommerburg, Olaf [VerfasserIn]   i
Titel:Magnetic resonance imaging of pulmonary and paranasal sinus abnormalities in children with primary ciliary dyskinesia compared to children with cystic fibrosis
Verf.angabe:Lena Wucherpfennig, Felix Wuennemann, Monika Eichinger, Niclas Schmitt, Angelika Seitz, Ingo Baumann, Jobst F. Roehmel, Mirjam Stahl, Susanne Hämmerling, Jaehi Chung, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Marcus A. Mall, Mark O. Wielpütz, Olaf Sommerburg
Jahr:2024
Umfang:11 S.
Fussnoten:Gesehen am 02.01.2025
Titel Quelle:Enthalten in: American Thoracic SocietyAnnals of the American Thoracic Society
Ort Quelle:New York, NY : American Thoracic Society, 2013
Jahr Quelle:2024
Band/Heft Quelle:21(2024), 3, Seite 438-448
ISSN Quelle:2325-6621
Abstract:Rationale: Primary ciliary dyskinesia (PCD) and cystic fibrosis (CF) are characterized by inherited impaired mucociliary clearance leading to chronic progressive lung disease as well as chronic rhinosinusitis (CRS). The diseases share morphological and functional commonalities on magnetic resonance imaging (MRI) of the lungs and paranasal sinuses, but comparative MRI studies are lacking. - - Objectives: To determine whether PCD shows different associations of pulmonary and paranasal sinus abnormalities on MRI and lung function test results in children (infants to adolescents) compared with children with CF. - - Methods: Eighteen children with PCD (median age, 9.5 [IQR, 3.4-12.7] yr; range, 0-18 yr) and 36 age-matched CF transmembrane conductance regulator modulator-naive children with CF (median age, 9.4 [3.4-13.2] yr; range, 0-18 yr) underwent same-session chest and paranasal sinus MRI as well as spirometry (to determine forced expiratory volume in 1 s percent predicted) and multiple-breath washout (to determine lung clearance index z-score). Pulmonary and paranasal sinus abnormalities were assessed using previously validated chest MRI and CRS-MRI scoring systems. - - Results: Mean chest MRI global score was similar in children with PCD and CF (15.0 [13.5-20.8] vs. 15.0 [9.0-15.0]; P = 0.601). Consolidations were more prevalent and severe in children with PCD (56% vs. 25% and 1.0 [0.0-2.8] vs. 0.0 [0.0-0.3], respectively; P < 0.05). The chest MRI global score correlated moderately with forced expiratory volume in 1 second percent predicted in children with PCD and children with CF (r = −0.523 and −0.687; P < 0.01) and with lung clearance index in children with CF (r = 0.650; P < 0.001) but not in PCD (r = 0.353; P = 0.196). CRS-MRI sum score and mucopyocele subscore were lower in children with PCD than in children with CF (27.5 [26.3-32.0] vs. 37.0 [37.8-40.0] and 2.0 [0.0-2.0] vs. 7.5 [4.8-9.0], respectively; P < 0.01). CRS-MRI sum score did not correlate with chest MRI score in PCD (r = 0.075-0.157; P = 0.557-0.788) but correlated moderately with MRI morphology score in CF (r = 0.437; P < 0.01). - - Conclusions: MRI detects differences in lung and paranasal sinus abnormalities between children with PCD and those with CF. Lung disease does not correlate with CRS in PCD but correlates in CF.
DOI:doi:10.1513/AnnalsATS.202305-453OC
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1513/AnnalsATS.202305-453OC
 Volltext: https://www.atsjournals.org/doi/10.1513/AnnalsATS.202305-453OC
 DOI: https://doi.org/10.1513/AnnalsATS.202305-453OC
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:airway disease
 CF
 chronic rhinosinusitis
 magnetic resonance imaging
 PCD
K10plus-PPN:191338473X
Verknüpfungen:→ Zeitschrift

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