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Verfasst von:Thomann, Anne K. [VerfasserIn]   i
 Schmitgen, Mike [VerfasserIn]   i
 Stephan, Jule C. [VerfasserIn]   i
 Ebert, Matthias [VerfasserIn]   i
 Thomann, Philipp [VerfasserIn]   i
 Szabo, Kristina [VerfasserIn]   i
 Reindl, Wolfgang [VerfasserIn]   i
 Wolf, Robert Christian [VerfasserIn]   i
Titel:Associations between brain morphology, inflammatory markers, and symptoms of fatigue, depression, or anxiety in active and remitted Crohn’s disease
Verf.angabe:Anne K. Thomann, Mike M. Schmitgen, Jule C. Stephan, Matthias P. Ebert, Philipp A. Thomann, Kristina Szabo, Wolfgang Reindl, R. Christian Wolf
E-Jahr:2024
Jahr:November 2024
Umfang:13 S.
Illustrationen:Illustrationen
Fussnoten:Online veröffentlicht: 17. Mai 2024 ; Gesehen am 07.01.2025
Titel Quelle:Enthalten in: Journal of Crohn's and Colitis
Ort Quelle:Oxford : Oxford Univ. Press, 2007
Jahr Quelle:2024
Band/Heft Quelle:18(2024), 11 vom: Nov., Seite 1767-1779
ISSN Quelle:1876-4479
Abstract:Fatigue and psychosocial impairments are highly prevalent in IBD, particularly during active disease. Disturbed brain-gut interactions may contribute to these symptoms. This study examined associations between brain structure, faecal calprotectin, and symptoms of fatigue, depression, and anxiety in persons with Crohn’s disease [CD] in different disease states.In this prospective observational study, n = 109 participants [n = 67 persons with CD, n = 42 healthy controls] underwent cranial magnetic resonance imaging, provided stool samples for analysis of faecal calprotectin, and completed questionnaires to assess symptoms of fatigue, depression, and anxiety. We analysed differences in grey matter volume [GMV] between patients and controls, and associations between regional GMV alterations, neuropsychiatric symptoms, and faecal calprotectin.Symptoms of fatigue, depression, and anxiety were increased in patients with CD compared with controls, with highest scores in active CD. Patients exhibited regionally reduced GMV in cortical and subcortical sensorimotor regions, occipitotemporal and medial frontal areas. Regional GMV differences showed a significant negative association with fatigue, but not with depression or anxiety. Subgroup analyses revealed symptom-GMV associations for fatigue in remitted but not in active CD, whereas fatigue was positively associated with faecal calprotectin in active but not in remitted disease.Our findings support disturbed brain-gut interactions in CD which may be particularly relevant for fatigue during remitted disease. Reduced GMV in the precentral gyrus and other sensorimotor areas could reflect key contributions to fatigue pathophysiology in CD. A sensorimotor model of fatigue in CD could also pave the way for novel treatment approaches.
DOI:doi:10.1093/ecco-jcc/jjae078
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1093/ecco-jcc/jjae078
 DOI: https://doi.org/10.1093/ecco-jcc/jjae078
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1913618374
Verknüpfungen:→ Zeitschrift

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