Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Behrendt, Marc [VerfasserIn]   i
Titel:Implications of TRPM3 and TRPM8 for sensory neuron sensitisation
Verf.angabe:Marc Behrendt
E-Jahr:2024
Jahr:1. Oktober 2024
Umfang:17 S.
Fussnoten:Gesehen am 07.01.2025
Titel Quelle:Enthalten in: Biological chemistry
Ort Quelle:Berlin [u.a.] : de Gruyter, 1996
Jahr Quelle:2024
Band/Heft Quelle:405(2024), 9-10, Seite 583-599
ISSN Quelle:1437-4315
Abstract:Sensory neurons serve to receive and transmit a wide range of information about the conditions of the world around us as well as the external and internal state of our body. Sensitisation of these nerve cells, i.e. becoming more sensitive to stimuli or the emergence or intensification of spontaneous activity, for example in the context of inflammation or nerve injury, can lead to chronic diseases such as neuropathic pain. For many of these disorders there are only very limited treatment options and in order to find and establish new therapeutic approaches, research into the exact causes of sensitisation with the elucidation of the underlying mechanisms and the identification of the molecular components is therefore essential. These components include plasma membrane receptors and ion channels that are involved in signal reception and transmission. Members of the transient receptor potential (TRP) channel family are also expressed in sensory neurons and some of them play a crucial role in temperature perception. This review article focuses on the heat-sensitive TRPM3 and the cold-sensitive TRPM8 (and TRPA1) channels and their importance in sensitisation of dorsal root ganglion sensory neurons is discussed based on studies related to inflammation and injury- as well as chemotherapy-induced neuropathy.
DOI:doi:10.1515/hsz-2024-0045
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1515/hsz-2024-0045
 Volltext: http://www.degruyter.com/document/doi/10.1515/hsz-2024-0045/html
 DOI: https://doi.org/10.1515/hsz-2024-0045
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chronic chemotherapy- or nerve injury-induced neuropathic pain rodent model
 cold and heat and mechanical nociception
 dorsal root ganglion sensory neuron peripheral sensitisation
 inflammation and colitis
 oxaliplatin
 temperature-sensitive transient receptor potential channel
K10plus-PPN:1913622134
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69287167   QR-Code
zum Seitenanfang