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| Verfasst von: | Badillo-Garcia, Luis Ernesto [VerfasserIn]  |
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| | Liu, Quan [VerfasserIn] |
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| | Ziebner, Kim [VerfasserIn] |
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| | Balduff, Michael [VerfasserIn] |
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| | Sevastyanova, Tatyana [VerfasserIn] |
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| | Schmuttermaier, Christina [VerfasserIn] |
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| | Klüter, Harald [VerfasserIn] |
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| | Harmsen, Martin [VerfasserIn] |
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| | Kzhyshkowska, Julia [VerfasserIn] |
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| Titel: | Hyperglycemia amplifies TLR-mediated inflammatory response of M(IL4) macrophages to dyslipidemic ligands |
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| Verf.angabe: | Luis Ernesto Badillo-Garcia, Quan Liu, Kim Ziebner, Michael Balduff, Tatyana Sevastyanova, Christina Schmuttermaier, Harald Klüter, Martin Harmsen, and Julia Kzhyshkowska |
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| E-Jahr: | 2024 |
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| Jahr: | July 2024 |
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| Umfang: | 8 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Gesehen am 08.01.2025 |
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| Titel Quelle: | Enthalten in: Journal of leukocyte biology |
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| Ort Quelle: | Kettering : Oxford University Press, 1984 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 116(2024), 1 vom: Juli, Seite 197-204 |
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| ISSN Quelle: | 1938-3673 |
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| Abstract: | Hyperglycemia is critical for initiation of diabetic vascular complications. We systemically addressed the role of hyperglycemia in the regulation of TLRs in primary human macrophages. Expression of TLRs (1-9) was examined in monocyte-derived M(NC), M(IFNγ), and M(IL4) differentiated in normoglycemic and hyperglycemic conditions. Hyperglycemia increased expression of TLR1 and TLR8 in M(NC), TLR2 and TLR6 in M(IFNγ), and TLR4 and TLR5 in M(IL4). The strongest effect of hyperglycemia in M(IL4) was the upregulation of the TLR4 gene and protein expression. Hyperglycemia amplified TLR4-mediated response of M(IL4) to lipopolysaccharide by significantly enhancing IL1β and modestly suppressing IL10 production. In M(IL4), hyperglycemia in combination with synthetic triacylated lipopeptide (TLR1/TLR2 ligand) amplified expression of TLR4 and production of IL1β. In summary, hyperglycemia enhanced the inflammatory potential of homeostatic, inflammatory, and healing macrophages by increasing specific profiles of TLRs. In combination with dyslipidemic ligands, hyperglycemia can stimulate a low-grade inflammatory program in healing macrophages supporting vascular diabetic complications. |
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| DOI: | doi:10.1093/jleuko/qiae050 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1093/jleuko/qiae050 |
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| | DOI: https://doi.org/10.1093/jleuko/qiae050 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1913800318 |
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| Verknüpfungen: | → Zeitschrift |
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Hyperglycemia amplifies TLR-mediated inflammatory response of M(IL4) macrophages to dyslipidemic ligands / Badillo-Garcia, Luis Ernesto [VerfasserIn]; July 2024 (Online-Ressource)
