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Verfasst von:Maurer, Martin H. [VerfasserIn]   i
 Haux-Nettesheim, Daniel [VerfasserIn]   i
 Unterberg, Andreas [VerfasserIn]   i
 Sakowitz, Oliver [VerfasserIn]   i
Titel:Proteomics of human cerebral microdialysate
Titelzusatz:from detection of biomarkers to clinical application
Verf.angabe:Martin H. Maurer, Daniel Haux, Andreas W. Unterberg, Oliver W. Sakowitz
E-Jahr:2008
Jahr:03 March 2008
Umfang:7 S.
Fussnoten:Gesehen am 13.01.2025
Weitere Titel:Titel des Special issue: Reviews 2008, part II
Titel Quelle:Enthalten in: Proteomics. Clinical applications
Ort Quelle:Weinheim : Wiley VCH, 2007
Jahr Quelle:2008
Band/Heft Quelle:2(2008), 3, special issue, Seite 437-443
ISSN Quelle:1862-8354
Abstract:Cerebral microdialysis is applied in clinical neurology and neurosurgery as monitoring tool in patients to evaluate the progression of severe diseases, such as stroke or trauma. Besides small molecules, e.g. metabolites and neurotransmitters, also the macromolecules, such as proteins and larger chemical compounds cross the dialysis membrane of the catheters implanted into the human brain parenchyma. Microdialysis can be used to extract molecules from the extracellular space of the brain in vivo, but additionally to deliver drugs, since the exchange is dependent on concentration gradients. Cerebral microdialysis may also be useful in the prediction of the clinical onset of symptoms, based on changes in the composition of pre-symptomatic microdialysate. For example, symptomatic vasospasm, which is a complication after subarachnoid hemorrhage, may be predicted by the combination of cerebral microdialysis and a proteomics approach. We will introduce the basic concepts of cerebral microdialysis, discuss possible clinical applications, and evaluate the application of proteomic approaches. With regard to technological aspects, we describe two-dimensional gel electrophoresis, high-pressure liquid chromatography, and mass spectrometry. With regard to clinical aspects, we discuss ethics, feasibility, time-course, and therapeutic options. In conclusion, proteomics of cerebral microdialysate may be used for diagnosis, disease monitoring, and therapeutic intervention of neurological patients.
DOI:doi:10.1002/prca.200780044
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/prca.200780044
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/prca.200780044
 DOI: https://doi.org/10.1002/prca.200780044
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biomarkers
 Microdialysis
 Neurology
 Stroke
K10plus-PPN:1914489578
Verknüpfungen:→ Zeitschrift

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