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Status: Bibliographieeintrag

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Verfasst von:Mick, Paul [VerfasserIn]   i
 Rohner, Marie [VerfasserIn]   i
 Renkawitz, Tobias [VerfasserIn]   i
 Lehner, Burkhard [VerfasserIn]   i
 Geisbüsch, Andreas [VerfasserIn]   i
 Tsitlakidis, Stefanos [VerfasserIn]   i
 Hariri, Mustafa [VerfasserIn]   i
 Deisenhofer, Julian [VerfasserIn]   i
 Müller, Michelle [VerfasserIn]   i
 Doll, Julian [VerfasserIn]   i
Titel:From benign lipoma to G3 liposarcoma
Titelzusatz:contrast-enhanced ultrasound reveals tumor microperfusion and indicates malignancy
Verf.angabe:Paul Mick, Marie Rohner, Tobias Renkawitz, Burkhard Lehner, Andreas Geisbüsch, Stefanos Tsitlakidis, Mustafa Hariri, Julian Deisenhofer, Michelle Müller, Julian Doll
E-Jahr:2024
Jahr:September 2024
Umfang:7 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar: 9. Juli 2024, Artikelversion: 2. August 2024 ; Gesehen am 14.01.2025
Titel Quelle:Enthalten in: Ultrasound in medicine & biology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1973
Jahr Quelle:2024
Band/Heft Quelle:50(2024), 9 vom: Sept., Seite 1472-1478
ISSN Quelle:1879-291X
Abstract:Objective - Lipomatous soft tissue tumors (STT), ranging from benign lipomas to malignant liposarcomas, require accurate differentiation for timely treatment. Complementary to MRI, Contrast-enhanced ultrasound (CEUS) is emerging as a promising tool, providing insight into tumor microperfusion in real-time. This study aims to explore the potential of preoperative CEUS in differentiating benign lipomatous tumors from malignant liposarcoma subtypes. - Methods - Eighty-seven patients with lipomatous STT scheduled for surgery were enrolled. Clinical and MRI assessments were conducted to obtain general tumor characteristics. CEUS was used for a standardized tumor perfusion evaluation. Perfusion analysis included peak enhancement, rise time, wash-in perfusion index, and wash-out rate, reflecting the perfusion kinetics. Histopathological results were obtained for every STT and compared to perfusion characteristics. - Results - In total, 48 lipoma, 23 ALT and 11 liposarcoma were identified. Significant differences in tumor microperfusion were demonstrated, with higher perfusion levels indicating higher malignancy (Peak enhancement [a.u.] of Lipoma: 145 ± 238; ALT: 268 ± 368; Liposarcoma: 3256 ± 4333; p (ALT vs. Liposarcoma) < 0.001). A perfusion-based identification of a benign lipoma or ALT versus sarcoma resulted in a positive predictive value of 93%. Patient-related factors (age, gender, BMI, ASA score, smoking status) had no significant impact on the CEUS-based perfusion parameters. - Conclusion - Our study suggests CEUS as a capable non-invasive tool for improving preoperative assessment of lipomatous STT. It can assist in the distinction between benign and malignant STT, accelerating treatment decisions and enhancing patient outcomes. Significant correlations between CEUS-derived parameters and malignancy highlight its risk assessment potential.
DOI:doi:10.1016/j.ultrasmedbio.2024.05.028
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.ultrasmedbio.2024.05.028
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0301562924002345
 DOI: https://doi.org/10.1016/j.ultrasmedbio.2024.05.028
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:CEUS
 Lipoma
 Liposarcoma
 Perfusion
 Soft tissue tumor
 Ultrasound
K10plus-PPN:1914515137
Verknüpfungen:→ Zeitschrift

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