Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Moreno, Nieves Mingo [VerfasserIn]  |
| Truschow, Pavel [VerfasserIn]  |
| Staiger, Jochen F. [VerfasserIn]  |
| Wagener, Jan Robin [VerfasserIn]  |
Titel: | Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain |
Verf.angabe: | Nieves Mingo-Moreno, Pavel Truschow, Jochen F. Staiger, Robin J. Wagener |
E-Jahr: | 2024 |
Jahr: | February 2024 |
Umfang: | 20 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 14.01.2025 |
Titel Quelle: | Enthalten in: Cerebral cortex |
Ort Quelle: | Oxford : Oxford Univ. Press, 1991 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 34(2024), 2 vom: Feb., Artikel-ID bhae023, Seite 1-20 |
ISSN Quelle: | 1460-2199 |
Abstract: | In mammalian neocortex development, every cohort of newborn neurons is guided toward the marginal zone, leading to an “inside-out” organization of the 6 neocortical layers. This migratory pattern is regulated by the extracellular glycoprotein Reelin. The reeler mouse shows a homozygous mutation of the reelin gene. Using RNA in situ hybridization we could demonstrate that the Reelin-deficient mouse cortex (male and female) displays an increasing lamination defect along the rostro-caudal axis that is characterized by strong cellular intermingling, but roughly reproduces the “inside-out” pattern in rostral cortex, while caudal cortex shows a relative inversion of neuronal positioning (“outside-in”). We found that in development of the reeler cortex, preplate-splitting is also defective with an increasing severity along the rostro-caudal axis. This leads to a misplacement of subplate neurons that are crucial for a switch in migration mode within the cortical plate. Using Flash Tag labeling and nucleoside analog pulse-chasing, we found an according migration defect within the cortical plate, again with a progressive severity along the rostro-caudal axis. Thus, loss of one key player in neocortical development leads to highly area-specific (caudally pronounced) developmental deficiencies that result in multiple roughly opposite rostral versus caudal adult neocortical phenotypes. |
DOI: | doi:10.1093/cercor/bhae023 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/cercor/bhae023 |
| Volltext: https://academic.oup.com/cercor/article/34/2/bhae023/7611065 |
| DOI: https://doi.org/10.1093/cercor/bhae023 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1914590392 |
Verknüpfungen: | → Zeitschrift |
Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain / Moreno, Nieves Mingo [VerfasserIn]; February 2024 (Online-Ressource)
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