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Verfasst von:Moreno, Nieves Mingo [VerfasserIn]   i
 Truschow, Pavel [VerfasserIn]   i
 Staiger, Jochen F. [VerfasserIn]   i
 Wagener, Jan Robin [VerfasserIn]   i
Titel:Caudally pronounced deficiencies in preplate splitting and migration underly a rostro-caudal progression of cortical lamination defects in the reeler brain
Verf.angabe:Nieves Mingo-Moreno, Pavel Truschow, Jochen F. Staiger, Robin J. Wagener
E-Jahr:2024
Jahr:February 2024
Umfang:20 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 14.01.2025
Titel Quelle:Enthalten in: Cerebral cortex
Ort Quelle:Oxford : Oxford Univ. Press, 1991
Jahr Quelle:2024
Band/Heft Quelle:34(2024), 2 vom: Feb., Artikel-ID bhae023, Seite 1-20
ISSN Quelle:1460-2199
Abstract:In mammalian neocortex development, every cohort of newborn neurons is guided toward the marginal zone, leading to an “inside-out” organization of the 6 neocortical layers. This migratory pattern is regulated by the extracellular glycoprotein Reelin. The reeler mouse shows a homozygous mutation of the reelin gene. Using RNA in situ hybridization we could demonstrate that the Reelin-deficient mouse cortex (male and female) displays an increasing lamination defect along the rostro-caudal axis that is characterized by strong cellular intermingling, but roughly reproduces the “inside-out” pattern in rostral cortex, while caudal cortex shows a relative inversion of neuronal positioning (“outside-in”). We found that in development of the reeler cortex, preplate-splitting is also defective with an increasing severity along the rostro-caudal axis. This leads to a misplacement of subplate neurons that are crucial for a switch in migration mode within the cortical plate. Using Flash Tag labeling and nucleoside analog pulse-chasing, we found an according migration defect within the cortical plate, again with a progressive severity along the rostro-caudal axis. Thus, loss of one key player in neocortical development leads to highly area-specific (caudally pronounced) developmental deficiencies that result in multiple roughly opposite rostral versus caudal adult neocortical phenotypes.
DOI:doi:10.1093/cercor/bhae023
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1093/cercor/bhae023
 Volltext: https://academic.oup.com/cercor/article/34/2/bhae023/7611065
 DOI: https://doi.org/10.1093/cercor/bhae023
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1914590392
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