The landscape of viral associations in human cancers

• Verfasst von: Zapatka, Marc [VerfasserIn]
• Verfasst von: Borozan, Ivan [VerfasserIn]
• Verfasst von: Brewer, Daniel S. [VerfasserIn]
• Verfasst von: ̇Iskar, Murat [VerfasserIn]
• Verfasst von: Grundhoff, Adam [VerfasserIn]
• Verfasst von: Alawi, Malik [VerfasserIn]
• Verfasst von: Desai, Nikita [VerfasserIn]
• Verfasst von: Sültmann, Holger [VerfasserIn]
• Verfasst von: Moch, Holger [VerfasserIn]
• Verfasst von: Cooper, Colin S. [VerfasserIn]
• Verfasst von: Eils, Roland [VerfasserIn]
• Verfasst von: Ferretti, Vincent [VerfasserIn]
• Verfasst von: Lichter, Peter [VerfasserIn]
• Titel: The landscape of viral associations in human cancers
• Verf.angabe: Marc Zapatka, Ivan Borozan, Daniel S. Brewer, Murat Iskar, Adam Grundhoff, Malik Alawi, Nikita Desai, Holger Sültmann, Holger Moch, Colin S. Cooper, Roland Eils, Vincent Ferretti, Peter Lichter
• E-Jahr: 2020
• Jahr: 05 February 2020
• Umfang: 11 S.
• Illustrationen: Illustrationen, Diagramme
• Fussnoten: Gesehen am 14.01.2025
• Titel Quelle: Enthalten in: Nature genetics
• Ort Quelle: London : Macmillan Publishers Limited, part of Springer Nature, 1992
• Jahr Quelle: 2020
• Band/Heft Quelle: 52(2020), 3, Seite 320-330
• ISSN Quelle: 1546-1718
• DOI: doi:10.1038/s41588-019-0558-9
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Errata: Zapatka, Marc, 1974 - : Author correction
• Sach-SW: Cancer
• K10plus-PPN: 1914594894

Abstract

Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein-Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma. For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was associated with local variations in genomic copy numbers. Integrations at the TERT promoter were associated with high telomerase expression evidently activating this tumor-driving process. High levels of endogenous retrovirus (ERV1) expression were linked to a worse survival outcome in patients with kidney cancer.