| Online-Ressource |
Verfasst von: | Hahnemann, Laura [VerfasserIn]  |
| Krämer, Anna Sabrina [VerfasserIn]  |
| Fink, Christoph Andreas [VerfasserIn]  |
| Jungk, Christine [VerfasserIn]  |
| Thomas, Michael [VerfasserIn]  |
| Christopoulos, Petros [VerfasserIn]  |
| Lischalk, Jonathan W [VerfasserIn]  |
| Meis, Jan [VerfasserIn]  |
| Hörner-Rieber, Juliane [VerfasserIn]  |
| Eichkorn, Tanja [VerfasserIn]  |
| Deng, Maximilian [VerfasserIn]  |
| Uzun-Lang, Kristin [VerfasserIn]  |
| Paul, Angela [VerfasserIn]  |
| Meixner, Eva [VerfasserIn]  |
| Weykamp, Fabian [VerfasserIn]  |
| Debus, Jürgen [VerfasserIn]  |
| König, Laila [VerfasserIn]  |
Titel: | Fractionated stereotactic radiotherapy of intracranial postoperative cavities after resection of brain metastases |
Titelzusatz: | clinical outcome and prognostic factors |
Verf.angabe: | L. Hahnemann, A. Krämer, C. Fink, C. Jungk, M. Thomas, P. Christopoulos, J. W. Lischalk, J. Meis, J. Hörner-Rieber, T. Eichkorn, M. Deng, K. Lang, A. Paul, E. Meixner, F. Weykamp, J. Debus, L. König |
E-Jahr: | 2024 |
Jahr: | 21 April 2024 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 17.01.2025 |
Titel Quelle: | Enthalten in: Clinical and translational radiation oncology |
Ort Quelle: | Amsterdam : Elsevier, 2016 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 46(2024), Artikel-ID 100782, Seite 100782-1-100782-10 |
ISSN Quelle: | 2405-6308 |
Abstract: | Background and Purpose - After surgical resection of brain metastases (BM), radiotherapy (RT) is indicated. Postoperative stereotactic radiosurgery (SRS) reduces the risk of local progression and neurocognitive decline compared to whole brain radiotherapy (WBRT). Aside from the optimal dose and fractionation, little is known about the combination of systemic therapy and postoperative fractionated stereotactic radiotherapy (fSRT), especially regarding tumour control and toxicity. - Methods - In this study, 105 patients receiving postoperative fSRT with 35 Gy in 7 fractions performed with Cyberknife were retrospectively reviewed. Overall survival (OS), local control (LC) and total intracranial brain control (TIBC) were analysed via Kaplan-Meier method. Cox proportional hazards models were used to identify prognostic factors. - Results - Median follow-up was 20.8 months. One-year TIBC was 61.6% and one-year LC was 98.6%. Median OS was 28.7 (95%-CI: 16.9-40.5) months. In total, local progression (median time not reached) occurred in 2.0% and in 20.4% radiation-induced contrast enhancements (RICE) of the cavity (after median of 14.3 months) were diagnosed. Absence of extracranial metastases was identified as an independent prognostic factor for superior OS (p = <0.001) in multivariate analyses, while a higher Karnofsky performance score (KPS) was predictive for longer OS in univariate analysis (p = 0.041). Leptomeningeal disease (LMD) developed in 13% of patients. - Conclusion - FSRT after surgical resection of BM is an effective and safe treatment approach with excellent local control and acceptable toxicity. Further prospective randomized trials are needed to establish standardized therapeutic guidelines. |
DOI: | doi:10.1016/j.ctro.2024.100782 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ctro.2024.100782 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S2405630824000594 |
| DOI: https://doi.org/10.1016/j.ctro.2024.100782 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Brain metastases |
| Fractionated stereotactic radiotherapy |
| Immunotherapy |
| Radiation-induced contrast enhancements |
| Resection cavity |
K10plus-PPN: | 1915078938 |
Verknüpfungen: | → Zeitschrift |
Fractionated stereotactic radiotherapy of intracranial postoperative cavities after resection of brain metastases / Hahnemann, Laura [VerfasserIn]; 21 April 2024 (Online-Ressource)