Prevalence and associations of dome-shaped maculas

• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Verfasst von: Panda-Jonas, Songhomitra [VerfasserIn]
• Verfasst von: Wei, Wen-Bin [VerfasserIn]
• Verfasst von: Xu, Jie [VerfasserIn]
• Verfasst von: Wang, Ya Xing [VerfasserIn]
• Titel: Prevalence and associations of dome-shaped maculas
• Titelzusatz: the Beijing Eye Study
• Verf.angabe: Jost B. Jonas, Songhomitra Panda-Jonas, Wen-Bin Wei, Jie Xu, Ya Xing Wang
• E-Jahr: 2024
• Jahr: March 2024
• Umfang: 9 S.
• Fussnoten: Erstmals veröffentlicht: 27. September 2024 ; Gesehen am 02.04.2025
• Titel Quelle: Enthalten in: Acta ophthalmologica
• Ort Quelle: Oxford : Blackwell, 2008
• Jahr Quelle: 2024
• Band/Heft Quelle: 103(2024), 2 vom: März, Seite 177-185
• ISSN Quelle: 1755-3768
• DOI: doi:10.1111/aos.16764
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: axial elongation
• Sach-SW: Beijing Eye Study
• Sach-SW: dome-shaped macula
• Sach-SW: high myopia
• Sach-SW: macular ridge
• Sach-SW: myopic macular degeneration
• Sach-SW: parapapillary scleral ridge
• Sach-SW: posterior staphyloma
• K10plus-PPN: 1915204712

Abstract

Purpose To explore the prevalence and associated factors of a dome-shaped macula (DSM) in a general population. Methods Out of the population-based Beijing Eye Study cohort (n = 3468 participants), the investigation included all eyes with an axial length of ≥25 mm, and a randomized sample of eyes with an axial length of <25 mm. Using optical coherence tomographic (OCT) images, we examined presence and height of DSMs, defined as an inward convexity of the foveal retinal pigment epithelium (RPE)/Bruch's membrane (BM) line, detectable in at least two OCT scans perpendicularly orientated to each other. Results The study cohort consisted of 366 eyes (314 individuals) with a mean age of 63.7 ± 9.7 years and a mean axial length of 24.8 ± 2.1 mm (median: 25.1 mm; range: 18.96-30.88 mm). Prevalence of DSMs (found in 6/366 eyes; 1.9%; 95%CI: 1.0, 3.0) increased from 0/125 (0%) in non-myopic eyes to 1/152 (0.7%; 95%CI: 0.0, 2.0) in moderately myopic eyes, and to 6/83 (7.2%; 95%CI: 1.7, 12.7) in the highly myopic group. In multivariable analysis, higher DSM prevalence corelated with longer axial length (OR: 2.05; 95%CI: 1.36, 3.08; p < 0.001) and higher stage of myopic macular degeneration (OR: 1.08; 95%CI: 1.01, 1.16; p = 0.03). The mean maximal DSM height was 139 ± 107 μm (median: 100 μm; range: 25-350 μm). It was associated with higher stage of myopic macular degeneration (beta: 0.24; p < 0.001) and higher prevalence of macular BM defects (beta: 0.17; p < 0.001). None of the DSMs showed a serous retinal detachment or relative choroidal thickening. Conclusions Higher DSM prevalence correlated non-linearly with longer axial length, with DSM height increasing with the presence of a BM defect. DSMs may be associated with an axial elongation-related BM overproduction in the fundus midperiphery in all meridians.