| |  Online-Ressource |
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| Verfasst von: | Zhang, Limei [VerfasserIn]  |
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| | Zetter, Mario A. [VerfasserIn] |
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| | Hernández, Vito S. [VerfasserIn] |
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| | Hernández-Pérez, Oscar R. [VerfasserIn] |
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| | Jáuregui-Huerta, Fernando [VerfasserIn] |
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| | Krabichler, Quirin [VerfasserIn] |
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| | Grinevich, Valéry [VerfasserIn] |
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| Titel: | Morphological signatures of neurogenesis and neuronal migration in hypothalamic vasopressinergic magnocellular nuclei of the adult rat |
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| Verf.angabe: | Limei Zhang, Mario A. Zetter, Vito S. Hernández, Oscar R. Hernández-Pérez, Fernando Jáuregui-Huerta, Quirin Krabichler and Valery Grinevich |
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| E-Jahr: | 2024 |
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| Jahr: | 26 June 2024 |
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| Umfang: | 25 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 23.01.2025 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 25(2024), 13, Artikel-ID 6988, Seite 1-25 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | The arginine vasopressin (AVP)-magnocellular neurosecretory system (AVPMNS) in the hypothalamus plays a critical role in homeostatic regulation as well as in allostatic motivational behaviors. However, it remains unclear whether adult neurogenesis exists in the AVPMNS. By using immunoreaction against AVP, neurophysin II, glial fibrillar acidic protein (GFAP), cell division marker (Ki67), migrating neuroblast markers (doublecortin, DCX), microglial marker (Ionized calcium binding adaptor molecule 1, Iba1), and 5′-bromo-2′-deoxyuridine (BrdU), we report morphological evidence that low-rate neurogenesis and migration occur in adult AVPMNS in the rat hypothalamus. Tangential AVP/GFAP migration routes and AVP/DCX neuronal chains as well as ascending AVP axonal scaffolds were observed. Chronic water deprivation significantly increased the BrdU+ nuclei within both the supraaoptic (SON) and paraventricular (PVN) nuclei. These findings raise new questions about AVPMNS’s potential hormonal role for brain physiological adaptation across the lifespan, with possible involvement in coping with homeostatic adversities. |
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| DOI: | doi:10.3390/ijms25136988 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms25136988 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/25/13/6988 |
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| | DOI: https://doi.org/10.3390/ijms25136988 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | BrdU |
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| | doublecortin (DCX) |
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| | hypothalamus |
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| | Ki67 |
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| | microglia |
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| | neurogenic niche |
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| | radial glial cells |
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| | vasopressin |
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| K10plus-PPN: | 1915462282 |
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| Verknüpfungen: | → Zeitschrift |
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Morphological signatures of neurogenesis and neuronal migration in hypothalamic vasopressinergic magnocellular nuclei of the adult rat / Zhang, Limei [VerfasserIn]; 26 June 2024 (Online-Ressource)
