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| Verfasst von: | Yin, Dwight E. [VerfasserIn]  |
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| | Palin, Amy C. [VerfasserIn] |
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| | Lombo, Tania B. [VerfasserIn] |
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| | Mahon, Robert N. [VerfasserIn] |
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| | Poon, Betty [VerfasserIn] |
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| | Wu, Da-Yu [VerfasserIn] |
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| | Atala, Anthony [VerfasserIn] |
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| | Brooks, Kristina M. [VerfasserIn] |
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| | Chen, Shuibing [VerfasserIn] |
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| | Coyne, Carolyn B. [VerfasserIn] |
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| | D’Souza, M. Patricia [VerfasserIn] |
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| | Fackler, Oliver Till [VerfasserIn] |
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| | Furler O’Brien, Robert L. [VerfasserIn] |
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| | Garcia-de-Alba, Carolina [VerfasserIn] |
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| | Jean-Philippe, Patrick [VerfasserIn] |
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| | Karn, Jonathan [VerfasserIn] |
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| | Majji, Sai [VerfasserIn] |
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| | Muotri, Alysson R. [VerfasserIn] |
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| | Ozulumba, Tochukwu [VerfasserIn] |
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| | Sakatis, Melanie Z. [VerfasserIn] |
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| | Schlesinger, Larry S. [VerfasserIn] |
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| | Singh, Anjali [VerfasserIn] |
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| | Spiegel, Hans M. L. [VerfasserIn] |
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| | Struble, Evi [VerfasserIn] |
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| | Sung, Kyung [VerfasserIn] |
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| | Tagle, Danilo A. [VerfasserIn] |
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| | Thacker, Vivek V. [VerfasserIn] |
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| | Tidball, Andrew M. [VerfasserIn] |
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| | Varthakavi, Vasundhara [VerfasserIn] |
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| | Vunjak-Novakovic, Gordana [VerfasserIn] |
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| | Wagar, Lisa E. [VerfasserIn] |
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| | Yeung, Catherine K. [VerfasserIn] |
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| | Ndhlovu, Lishomwa C. [VerfasserIn] |
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| | Ott, Melanie [VerfasserIn] |
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| Titel: | 3D human tissue models and microphysiological systems for HIV and related comorbidities |
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| Verf.angabe: | Dwight E. Yin, Amy C. Palin, Tania B. Lombo, Robert N. Mahon, Betty Poon, Da-Yu Wu, Anthony Atala, Kristina M. Brooks, Shuibing Chen, Carolyn B. Coyne, M. Patricia D’Souza, Oliver T. Fackler, Robert L. Furler O’Brien, Carolina Garcia-de-Alba, Patrick Jean-Philippe, Jonathan Karn, Sai Majji, Alysson R. Muotri, Tochukwu Ozulumba, Melanie Z. Sakatis, Larry S. Schlesinger, Anjali Singh, Hans M.L. Spiegel, Evi Struble, Kyung Sung, Danilo A. Tagle, Vivek V. Thacker, Andrew M. Tidball, Vasundhara Varthakavi, Gordana Vunjak-Novakovic, Lisa E. Wagar, Catherine K. Yeung, Lishomwa C. Ndhlovu, Melanie Ott |
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| E-Jahr: | 2024 |
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| Jahr: | May 2024 |
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| Umfang: | 18 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar 8 December 2023, Version des Artikels 1 May 2024 ; Gesehen am 24.01.2025 |
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| Titel Quelle: | Enthalten in: Trends in biotechnology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1983 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 42(2024), 5 vom: Mai, Seite 526-543 |
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| ISSN Quelle: | 1879-3096 |
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| Abstract: | Three-dimensional (3D) human tissue models/microphysiological systems (e.g., organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and have potential to address critical questions, including characterization of viral reservoirs, insufficient innate and adaptive immune responses, biomarker discovery and evaluation, medical complexity with comorbidities (e.g., tuberculosis and SARS-CoV-2), and protection and transmission during pregnancy and birth. Composed of multiple primary or stem cell-derived cell types organized in a dedicated 3D space, these systems hold unique promise for better reproducing human physiology, advancing therapeutic development, and bridging the human-animal model translational gap. Here, we discuss the promises and achievements with 3D human tissue models in HIV and comorbidity research, along with remaining barriers with respect to cell biology, virology, immunology, and regulatory issues. |
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| DOI: | doi:10.1016/j.tibtech.2023.10.008 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.tibtech.2023.10.008 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0167779923002998 |
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| | DOI: https://doi.org/10.1016/j.tibtech.2023.10.008 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | explant |
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| | HIV/AIDS |
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| | microphysiological system |
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| | organ-chip |
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| | organoid |
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| | tuberculosis |
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| K10plus-PPN: | 1915534895 |
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| Verknüpfungen: | → Zeitschrift |
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3D human tissue models and microphysiological systems for HIV and related comorbidities / Yin, Dwight E. [VerfasserIn]; May 2024 (Online-Ressource)
