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| Verfasst von: | Steinberg, Hannah Luisa [VerfasserIn]  |
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| | Ting, Saskia C [VerfasserIn] |
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| | Zensen, Sebastian [VerfasserIn] |
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| | Ludwig, Johannes Maximilian [VerfasserIn] |
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| | Li, Yan [VerfasserIn] |
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| | Richly, Heike [VerfasserIn] |
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| | Grüneisen, Johannes [VerfasserIn] |
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| | Siveke, Jens T [VerfasserIn] |
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| | Theysohn, Jens M [VerfasserIn] |
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| | Schaarschmidt, Benedikt M [VerfasserIn] |
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| Titel: | Are histomorphological patterns a predictor for survival in uveal melanoma patients with hepatic metastases undergoing hepatic artery infusion chemotherapy? |
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| Titelzusatz: | Medical imaging : radiation oncology |
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| Verf.angabe: | Hannah L Steinberg-Vorhoff, Saskia C Ting, Sebastian Zensen, Johannes M Ludwig, Yan Li, Heike Richly, Johannes Grüneisen, Jens T Siveke, Jens M Theysohn and Benedikt M Schaarschmidt |
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| E-Jahr: | 2024 |
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| Jahr: | October 2024 |
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| Umfang: | 8 S. |
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| Fussnoten: | Erstmals veröffentlicht: 24. September 2024 ; Gesehen am 27.01.2025 |
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| Titel Quelle: | Enthalten in: Journal of medical imaging and radiation oncology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 2008 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 68(2024), 7 vom: Okt., Seite 862-869 |
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| ISSN Quelle: | 1754-9485 |
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| Abstract: | Introduction In uveal melanoma (UM) patients with hepatic metastases, hepatic artery infusion chemotherapy (HAIC) is a viable, palliative treatment option. To evaluate the impact of two histomorphological patterns (spindle cell vs. epithelioid) of liver metastases on median overall survival (mOS) in UM patients undergoing HAIC. Methods A retrospective analysis with 60 UM patients (29 females, mean age: 61.6 ± 12.1 years) with hepatic metastases was performed. Histomorphological patterns in metastases were analysed and classified as either predominant spindle cell or epithelioid pattern. mOS between both patient groups was analysed using Kaplan-Meier curves and the log-rank test. Results In 73.3% (44/60) of the metastases, a predominant epithelioid pattern, in 21.7% (13/60) a predominant spindle cell pattern, and in 5% (3/60) other patterns were found. No significant differences between patients with an epithelioid (mOS: 14.2 months, 95% CI: 8.8-19.6) and a spindle cell pattern (mOS: 14.4 months, 95% CI: 4.3-24.5) were detected by the log-rank test, χ2(2) = 0.22, P = 0.881. Conclusion Histomorphological patterns of UM metastases do not seem to be a predictor for mOS in UM patients undergoing HAIC. |
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| DOI: | doi:10.1111/1754-9485.13783 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1111/1754-9485.13783 |
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| | kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/1754-9485.13783 |
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| | DOI: https://doi.org/10.1111/1754-9485.13783 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | HAIC |
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| | hepatic artery infusion therapy |
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| | histomorphological pattern |
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| | prognosis |
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| | survival |
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| K10plus-PPN: | 1915633699 |
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| Verknüpfungen: | → Zeitschrift |
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Are histomorphological patterns a predictor for survival in uveal melanoma patients with hepatic metastases undergoing hepatic artery infusion chemotherapy? / Steinberg, Hannah Luisa [VerfasserIn]; October 2024 (Online-Ressource)
