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Verfasst von:Scherf-Clavel, Maike [VerfasserIn]   i
 Baumann, Pierre [VerfasserIn]   i
 Hart, Xenia Marlene [VerfasserIn]   i
 Schneider, Heike [VerfasserIn]   i
 Schoretsanitis, Georgios [VerfasserIn]   i
 Steimer, Werner [VerfasserIn]   i
 Zernig, Gerald [VerfasserIn]   i
 Zurek, Gabriela [VerfasserIn]   i
Titel:Behind the curtain
Titelzusatz:therapeutic drug monitoring of psychotropic drugs from a laboratory analytical perspective
Verf.angabe:Maike Scherf-Clavel, Pierre Baumann, Xenia M. Hart, Heike Schneider, Georgios Schoretsanitis, Werner Steimer, Gerald Zernig, Gabriela Zurek
E-Jahr:2024
Jahr:April 2024
Umfang:?
Fussnoten:Gesehen am 28.01.2025
Titel Quelle:Enthalten in: Therapeutic drug monitoring
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1979
Jahr Quelle:2024
Band/Heft Quelle:46(2024), 2 vom: Apr., Seite 143-154
ISSN Quelle:1536-3694
Abstract:Purpose: - Therapeutic drug monitoring (TDM) is a well-established tool for guiding psychopharmacotherapy and improving patient care. Despite their established roles in the prescription of psychotropic drugs, the “behind the curtain” processes of TDM requests are invariably obscure to clinicians, and literature addressing this topic is scarce. - Methods: - In the present narrative review, we provide a comprehensive overview of the various steps, starting from requesting TDM to interpreting TDM findings, in routine clinical practice. Our goal was to improve clinicians' insights into the numerous factors that may explain the variations in TDM findings due to methodological issues. - Results: - We discussed challenges throughout the TDM process, starting from the analyte and its major variation forms, through sampling procedures and pre-analytical conditions, time of blood sampling, sample matrices, and collection tubes, to analytical methods, their advantages and shortcomings, and the applied quality procedures. Additionally, we critically reviewed the current and future advances in the TDM of psychotropic drugs. - Conclusions: -The “behind the curtain” processes enabling TDM involve a multidisciplinary team, which faces numerous challenges in clinical routine. A better understanding of these processes will allow clinicians to join the efforts for achieving higher-quality TDM findings, which will in turn improve treatment effectiveness and safety outcomes of psychotropic agents.
DOI:doi:10.1097/FTD.0000000000001092
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/FTD.0000000000001092
 Volltext: https://journals.lww.com/drug-monitoring/abstract/2024/04000/behind_the_curtain__therapeutic_drug_monitoring_of.4.aspx
 DOI: https://doi.org/10.1097/FTD.0000000000001092
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:191573956X
Verknüpfungen:→ Zeitschrift

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