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Verfasst von:Chen, Qiushi [VerfasserIn]   i
 Fan, Yiwen [VerfasserIn]   i
 Huang, Ke [VerfasserIn]   i
 Li, Wei [VerfasserIn]   i
 Geldsetzer, Pascal [VerfasserIn]   i
 Bärnighausen, Till [VerfasserIn]   i
 Yang, Ting [VerfasserIn]   i
 Wang, Chen [VerfasserIn]   i
 Chen, Simiao [VerfasserIn]   i
Titel:Cost-effectiveness of population-based screening for chronic obstructive pulmonary disease in China
Titelzusatz:a simulation modeling study
Verf.angabe:Qiushi Chen, Yiwen Fan, Ke Huang, Wei Li, Pascal Geldsetzer, Till Bärnighausen, Ting Yang, Chen Wang and Simiao Chen
E-Jahr:2024
Jahr:May 2024
Umfang:13 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 28.01.2025
Titel Quelle:Enthalten in: The lancet. Regional Health. Western Pacific
Ort Quelle:[Amsterdam] : Elsevier, 2020
Jahr Quelle:2024
Band/Heft Quelle:46(2024) vom: Mai, Artikel-ID 101065, Seite 1-13
ISSN Quelle:2666-6065
Abstract:Background - China has the highest disease burden of chronic obstructive pulmonary disease (COPD) in the world; however, the diagnosis rate remains low. Screening for COPD in the population may improve early diagnosis and long-term health outcomes for patients with COPD. In this study, we aimed to evaluate the cost-effectiveness of population-based COPD screening policies in China. - Methods - We developed a microsimulation model that simulated incidence, natural history, and clinical management of COPD over a lifetime horizon among the general population aged 35-80 years in China. We evaluated population-based screening policies with different screening methods (one-step with COPD Screening Questionnaire or two-step with additional portable spirometer test) and frequencies (one-time or every 1-10 years). We calculated the incremental cost-effectiveness ratio (ICER) of the screening policies compared with the status quo (without screening) and identified the most cost-effective screening policy. Scenario and sensitivity analyses were performed to assess the impact of key parameters and the robustness of model results. - Findings - Compared with the status quo, all population-based COPD screening policies were cost-effective with estimated ICERs ranging between $8034 and $13,209 per quality-adjusted-life-year (QALY), all under the willingness-to-pay value of $38,441/QALY (three times China's gross domestic product per capita). A total of 0.39%-8.10% of COPD-related deaths and 0.58%-2.70% of COPD exacerbations were projected to be averted by COPD screening. Among all screening policies, annual two-step screening was the most cost-effective. Improving the linkage from screening to diagnosis and treatment could further increase population health benefits and the cost-effectiveness of COPD screening. - Interpretation - Population-based screening for COPD could be cost-effective in China. Offering public programs for COPD screening similar to existing preventive health services for other chronic diseases could be a promising strategy to improve population health outcomes and mitigate the disease burden of COPD in China. - Funding - Alexander von Humboldt Foundation, National Natural Science Foundation of China, CAMS Innovation Fund for Medical Science, Chinese Academy of Engineering project, and Horizon Europe.
DOI:doi:10.1016/j.lanwpc.2024.101065
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.lanwpc.2024.101065
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2666606524000592
 DOI: https://doi.org/10.1016/j.lanwpc.2024.101065
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chronic obstructive pulmonary disease
 Cost-effectiveness analysis
 Microsimulation
 Population-based screening
 Public health policy
K10plus-PPN:1915742269
Verknüpfungen:→ Zeitschrift

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