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Verfasst von:Forner, Jan [VerfasserIn]   i
 Weidner, Kathrin [VerfasserIn]   i
 Rusnak, Jonas [VerfasserIn]   i
 Dudda, Jonas [VerfasserIn]   i
 Behnes, Michael [VerfasserIn]   i
 Akın, Ibrahim [VerfasserIn]   i
 Schupp, Tobias [VerfasserIn]   i
Titel:Prognostic impact of left compared to right heart function in sepsis and septic shock
Verf.angabe:Jan Forner, Kathrin Weidner, Jonas Rusnak, Jonas Dudda, Michael Behnes, Ibrahim Akin, Tobias Schupp
E-Jahr:2024
Jahr:June 2024
Umfang:8 S.
Fussnoten:Gesehen am 29.01.2025
Titel Quelle:Enthalten in: American Society for Artificial Internal OrgansASAIO journal
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1992
Jahr Quelle:2024
Band/Heft Quelle:70(2024), 6, Seite 502-509
ISSN Quelle:1538-943X
Abstract:This study investigates the prognostic impact of left ventricular ejection fraction (LVEF) and tricuspid annular plane systolic excursion (TAPSE) in patients with sepsis and septic shock. Consecutive patients with sepsis and septic shock were included from 2019 to 2021. LVEF and TAPSE were assessed during the first 24 hours of intensive care unit (ICU) treatment. Patients were stratified by LVEF of less than 45% and greater than or equal to 45%. The primary endpoint was 30 day all-cause mortality. Two hundred ninety-two consecutive patients were included, of which 26% presented with LVEF of less than 45%. Within the entire study cohort (60% vs. 48%; hazard ratio [HR] = 1.414; 95% confidence interval [CI] = 0.999-2.001; p = 0.050) and specifically in patients with sepsis (58% vs. 36%; HR = 1.919; 95% CI = 1.148-3.208; p = 0.013), LVEF of less than 45% was associated with an increased risk of 30 day all-cause mortality, whereas TAPSE of less than 17 mm was not (56% vs. 52%; log rank p = 0.798). Even after multivariable adjustment, LVEF of less than 45% was accompanied by a worse prognosis in septic patients (HR = 1.944; 95% CI = 1.084-3.485; p = 0.026). Contrarily, LVEF < 45% was not accompanied with increased mortality in septic shock patients (63% vs. 67%; log rank p = 0.847; HR = 0.956; 95% CI 0.596-1.533; p = 0.853). In conclusion, impaired LVEF was associated with increased mortality in septic patients without shock, but not in patients with septic shock. In contrast, impaired right ventricular function was not associated with adverse prognosis in both conditions.
DOI:doi:10.1097/MAT.0000000000002131
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/MAT.0000000000002131
 Volltext: https://journals.lww.com/asaiojournal/abstract/2024/06000/prognostic_impact_of_left_compared_to_right_heart.7.aspx
 DOI: https://doi.org/10.1097/MAT.0000000000002131
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1915870364
Verknüpfungen:→ Zeitschrift

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