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Verfasst von:Stoop, Thomas F. [VerfasserIn]   i
 Oba, Atsushi [VerfasserIn]   i
 Wu, Y. H. Andrew [VerfasserIn]   i
 Beaty, Laurel E. [VerfasserIn]   i
 Colborn, Kathryn L. [VerfasserIn]   i
 Janssen, Boris V. [VerfasserIn]   i
 Al-Musawi, Mohammed H. [VerfasserIn]   i
 Franco, Salvador Rodriguez [VerfasserIn]   i
 Sugawara, Toshitaka [VerfasserIn]   i
 Franklin, Oskar [VerfasserIn]   i
 Jain, Ajay [VerfasserIn]   i
 Saiura, Akio [VerfasserIn]   i
 Sauvanet, Alain [VerfasserIn]   i
 Coppola, Alessandro [VerfasserIn]   i
 Javed, Ammar A. [VerfasserIn]   i
 Groot Koerkamp, Bas [VerfasserIn]   i
 Miller, Braden N. [VerfasserIn]   i
 Mack, Claudia [VerfasserIn]   i
 Hashimoto, Daisuke [VerfasserIn]   i
 Caputo, Damiano [VerfasserIn]   i
 Kleive, Dyre [VerfasserIn]   i
 Sereni, Elisabetta [VerfasserIn]   i
 Belfiori, Giulio [VerfasserIn]   i
 Ichida, Hirofumi [VerfasserIn]   i
 van Dam, Jacob L. [VerfasserIn]   i
 Dembinski, Jeanne [VerfasserIn]   i
 Akahoshi, Keiichi [VerfasserIn]   i
 Roberts, Keith J. [VerfasserIn]   i
 Tanaka, Kimitaka [VerfasserIn]   i
 Labori, Knut J. [VerfasserIn]   i
 Falconi, Massimo [VerfasserIn]   i
 House, Michael G. [VerfasserIn]   i
 Sugimoto, Motokazu [VerfasserIn]   i
 Tanabe, Minoru [VerfasserIn]   i
 Gotohda, Naoto [VerfasserIn]   i
 Krohn, Paul S. [VerfasserIn]   i
 Burkhart, Richard A. [VerfasserIn]   i
 Thakkar, Rohan G. [VerfasserIn]   i
 Pande, Rupaly [VerfasserIn]   i
 Dokmak, Safi [VerfasserIn]   i
 Hirano, Satoshi [VerfasserIn]   i
 Burgdorf, Stefan K. [VerfasserIn]   i
 Crippa, Stefano [VerfasserIn]   i
 van Roessel, Stijn [VerfasserIn]   i
 Satoi, Sohei [VerfasserIn]   i
 White, Steven A. [VerfasserIn]   i
 Hackert, Thilo [VerfasserIn]   i
 Nguyen, Trang K. [VerfasserIn]   i
 Yamamoto, Tomohisa [VerfasserIn]   i
 Nakamura, Toru [VerfasserIn]   i
 Bachu, Vismaya [VerfasserIn]   i
 Burns, William R. [VerfasserIn]   i
 Inoue, Yosuke [VerfasserIn]   i
 Takahashi, Yu [VerfasserIn]   i
 Ushida, Yuta [VerfasserIn]   i
 Aslami, Zohra V. [VerfasserIn]   i
 Verbeke, Caroline S. [VerfasserIn]   i
 Fariña, Arantza [VerfasserIn]   i
 He, Jin [VerfasserIn]   i
 Wilmink, Johanna W. [VerfasserIn]   i
 Messersmith, Wells [VerfasserIn]   i
 Verheij, Joanne [VerfasserIn]   i
 Kaplan, Jeffrey [VerfasserIn]   i
 Schulick, Richard D. [VerfasserIn]   i
 Besselink, Marc G. [VerfasserIn]   i
 Del Chiaro, Marco [VerfasserIn]   i
Titel:Pathological complete response in patients with resected pancreatic adenocarcinoma after preoperative chemotherapy
Verf.angabe:Thomas F. Stoop, MD; Atsushi Oba, MD, PhD; Y.H. Andrew Wu, MD; Laurel E. Beaty, MSc; Kathryn L. Colborn, PhD; Boris V. Janssen, BSc; Mohammed H. Al-Musawi, MD, MBChB, MSc; Salvador Rodriguez Franco, MD; Toshitaka Sugawara, MD, PhD; Oskar Franklin, MD, PhD; Ajay Jain, MD; Akio Saiura, MD, PhD; Alain Sauvanet, MD, PhD; Alessandro Coppola, MD, PhD; Ammar A. Javed, MD; Bas Groot Koerkamp, MD, PhD; Braden N. Miller, MD; Claudia E. Mack, MD; Daisuke Hashimoto, MD, PhD; Damiano Caputo, MD; Dyre Kleive, MD, PhD; Elisabetta Sereni, MD; Giulio Belfiori, MD; Hirofumi Ichida, MD, PhD; Jacob L. van Dam, MD; Jeanne Dembinski, MD; Keiichi Akahoshi, MD, PhD; Keith J. Roberts, MD, PhD; Kimitaka Tanaka, MD, PhD; Knut J. Labori, MD, PhD; Massimo Falconi, MD, PhD; Michael G. House, MD; Motokazu Sugimoto, MD, PhD; Minoru Tanabe, MD, PhD; Naoto Gotohda, MD, PhD; Paul S. Krohn, MD; Richard A. Burkhart, MD; Rohan G. Thakkar, MD; Rupaly Pande, BSc; Safi Dokmak, MD, PhD; Satoshi Hirano, MD, PhD; Stefan K. Burgdorf, MD, PhD; Stefano Crippa, MD, PhD; Stijn van Roessel, MD, PhD; Sohei Satoi, MD, PhD; Steven A. White, MD; Thilo Hackert, MD, PhD; Trang K. Nguyen, MD; Tomohisa Yamamoto, MD, PhD; Toru Nakamura, MD, PhD; Vismaya Bachu, MD; William R. Burns, MD; Yosuke Inoue, MD, PhD; Yu Takahashi, MD, PhD; Yuta Ushida, MD; Zohra V. Aslami, BA; Caroline S. Verbeke, MD, PhD; Arantza Fariña, MD, PhD; Jin He, MD, PhD; Johanna W. Wilmink, MD, PhD; Wells Messersmith, MD; Joanne Verheij, MD, PhD; Jeffrey Kaplan, MD; Richard D. Schulick, MD, MBA; Marc G. Besselink, MD, PhD; Marco Del Chiaro, MD, PhD
E-Jahr:2024
Jahr:June 18, 2024
Umfang:19 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 31.01.2025
Titel Quelle:Enthalten in: JAMA network open
Ort Quelle:Chicago, Ill. : American Medical Association, 2018
Jahr Quelle:2024
Band/Heft Quelle:7(2024), 6, Artikel-ID e2417625, Seite 1-19
ISSN Quelle:2574-3805
Abstract:Preoperative chemo(radio)therapy is increasingly used in patients with localized pancreatic adenocarcinoma, leading to pathological complete response (pCR) in a small subset of patients. However, multicenter studies with in-depth data about pCR are lacking.To investigate the incidence, outcome, and risk factors of pCR after preoperative chemo(radio)therapy.This observational, international, multicenter cohort study assessed all consecutive patients with pathology-proven localized pancreatic adenocarcinoma who underwent resection after 2 or more cycles of chemotherapy (with or without radiotherapy) in 19 centers from 8 countries (January 1, 2010, to December 31, 2018). Data collection was performed from February 1, 2020, to April 30, 2022, and analyses from January 1, 2022, to December 31, 2023. Median follow-up was 19 months.Preoperative chemotherapy (with or without radiotherapy) followed by resection.The incidence of pCR (defined as absence of vital tumor cells in the sampled pancreas specimen after resection), its association with OS from surgery, and factors associated with pCR. Factors associated with overall survival (OS) and pCR were investigated with Cox proportional hazards and logistic regression models, respectively.Overall, 1758 patients (mean [SD] age, 64 [9] years; 879 [50.0%] male) were studied. The rate of pCR was 4.8% (n = 85), and pCR was associated with OS (hazard ratio, 0.46; 95% CI, 0.26-0.83). The 1-, 3-, and 5-year OS rates were 95%, 82%, and 63% in patients with pCR vs 80%, 46%, and 30% in patients without pCR, respectively (P < .001). Factors associated with pCR included preoperative multiagent chemotherapy other than (m)FOLFIRINOX ([modified] leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin) (odds ratio [OR], 0.48; 95% CI, 0.26-0.87), preoperative conventional radiotherapy (OR, 2.03; 95% CI, 1.00-4.10), preoperative stereotactic body radiotherapy (OR, 8.91; 95% CI, 4.17-19.05), radiologic response (OR, 13.00; 95% CI, 7.02-24.08), and normal(ized) serum carbohydrate antigen 19-9 after preoperative therapy (OR, 3.76; 95% CI, 1.79-7.89).This international, retrospective cohort study found that pCR occurred in 4.8% of patients with resected localized pancreatic adenocarcinoma after preoperative chemo(radio)therapy. Although pCR does not reflect cure, it is associated with improved OS, with a doubled 5-year OS of 63% compared with 30% in patients without pCR. Factors associated with pCR related to preoperative chemo(radio)therapy regimens and anatomical and biological disease response features may have implications for treatment strategies that require validation in prospective studies because they may not universally apply to all patients with pancreatic adenocarcinoma.
DOI:doi:10.1001/jamanetworkopen.2024.17625
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1001/jamanetworkopen.2024.17625
 DOI: https://doi.org/10.1001/jamanetworkopen.2024.17625
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:191608141X
Verknüpfungen:→ Zeitschrift

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