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Status: Bibliographieeintrag

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Verfasst von:Vuong, Nguyen Lam [VerfasserIn]   i
 Quyen, Nguyen Than Ha [VerfasserIn]   i
 Tien, Nguyen Thi Hanh [VerfasserIn]   i
 Duong Thi Hue, Kien [VerfasserIn]   i
 Duyen, Huynh Thi Le [VerfasserIn]   i
 Lam, Phung Khanh [VerfasserIn]   i
 Tam, Dong Thi Hoai [VerfasserIn]   i
 Van Ngoc, Tran [VerfasserIn]   i
 Jänisch, Thomas [VerfasserIn]   i
 Simmons, Cameron P. [VerfasserIn]   i
 Yacoub, Sophie [VerfasserIn]   i
 Wills, Bridget A. [VerfasserIn]   i
 Geskus, Ronald [VerfasserIn]   i
Titel:Dengue viremia kinetics and effects on platelet count and clinical outcomes
Titelzusatz:an analysis of 2340 patients from Vietnam
Verf.angabe:Nguyen Lam Vuong, Nguyen Than Ha Quyen, Nguyen Thi Hanh Tien, Kien Duong Thi Hue, Huynh Thi Le Duyen, Phung Khanh Lam, Dong Thi Hoai Tam, Tran Van Ngoc, Thomas Jaenisch, Cameron P. Simmons, Sophie Yacoub, Bridget A. Wills, Ronald Geskus
E-Jahr:2024
Jahr:21 June 2024
Umfang:45 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 31.01.2025
Titel Quelle:Enthalten in: eLife
Ort Quelle:Cambridge : eLife Sciences Publications, 2012
Jahr Quelle:2024
Band/Heft Quelle:13(2024) vom: Juni, Artikel-ID RP92606, Seite 1-45
ISSN Quelle:2050-084X
Abstract:BACKGROUND: Viremia is a critical factor in understanding the pathogenesis of dengue infection, but limited data exist on viremia kinetics. This study aimed to investigate the kinetics of viremia and its effects on subsequent platelet count, severe dengue, and plasma leakage. - METHODS: We pooled data from three studies conducted in Vietnam between 2000 and 2016, involving 2340 dengue patients with daily viremia measurements and platelet counts after symptom onset. Viremia kinetics were assessed using a random effects model that accounted for left-censored data. The effects of viremia on subsequent platelet count and clinical outcomes were examined using a landmark approach with a random effects model and logistic regression model with generalized estimating equations, respectively. The rate of viremia decline was derived from the model of viremia kinetics. Its effect on the clinical outcomes was assessed by logistic regression models. - RESULTS: Viremia levels rapidly decreased following symptom onset, with variations observed depending on the infecting serotype. DENV-1 exhibited the highest mean viremia levels during the first 5-6 days, while DENV-4 demonstrated the shortest clearance time. Higher viremia levels were associated with decreased subsequent platelet counts from day 6 onwards. Elevated viremia levels on each illness day increased the risk of developing severe dengue and plasma leakage. However, the effect size decreased with later illness days. A more rapid decline in viremia is associated with a reduced risk of the clinical outcomes. - CONCLUSIONS: This study provides comprehensive insights into viremia kinetics and its effect on subsequent platelet count and clinical outcomes in dengue patients. Our findings underscore the importance of measuring viremia levels during the early febrile phase for dengue studies and support the use of viremia kinetics as outcome for phase-2 dengue therapeutic trials. - FUNDING: Wellcome Trust and European Union Seventh Framework Programme.
DOI:doi:10.7554/eLife.92606
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.7554/eLife.92606
 DOI: https://doi.org/10.7554/eLife.92606
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescent
 Adult
 dengue
 Dengue
 Dengue Virus
 Female
 Humans
 Kinetics
 Male
 medicine
 Middle Aged
 plasma leakage
 platelet
 Platelet Count
 severe dengue
 Vietnam
 viremia
 Viremia
 viruses
 Young Adult
K10plus-PPN:1916114563
Verknüpfungen:→ Zeitschrift

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