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| Verfasst von: | Zillich, Lea [VerfasserIn]  |
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| | Çetin, Metin [VerfasserIn] |
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| | Hummel, Elisabeth M. [VerfasserIn] |
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| | Zillich, Eric [VerfasserIn] |
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| | Fries, Gabriel R. [VerfasserIn] |
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| | Frank, Josef [VerfasserIn] |
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| | Streit, Fabian [VerfasserIn] |
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| | Foo, Jerome Clifford [VerfasserIn] |
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| | Sirignano, Lea [VerfasserIn] |
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| | Friske, Marion [VerfasserIn] |
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| | Lenz, Bernd [VerfasserIn] |
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| | Hoffmann, Sabine [VerfasserIn] |
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| | Adorjan, Krisztina [VerfasserIn] |
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| | Kiefer, Falk [VerfasserIn] |
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| | Bakalkin, Georgy [VerfasserIn] |
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| | Hansson, Anita C. [VerfasserIn] |
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| | Lohoff, Falk W. [VerfasserIn] |
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| | Kärkkäinen, Olli [VerfasserIn] |
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| | Kok, Eloise [VerfasserIn] |
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| | Karhunen, Pekka J. [VerfasserIn] |
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| | Sutherland, Greg T. [VerfasserIn] |
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| | Walss-Bass, Consuelo [VerfasserIn] |
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| | Spanagel, Rainer [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| | Moser, Dirk [VerfasserIn] |
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| | Witt, Stephanie [VerfasserIn] |
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| Titel: | Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder |
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| Verf.angabe: | Lea Zillich, Metin Cetin, Elisabeth M. Hummel, Eric Poisel, Gabriel R. Fries, Josef Frank, Fabian Streit, Jerome C. Foo, Lea Sirignano, Marion M. Friske, Bernd Lenz, Sabine Hoffmann, Kristina Adorjan, Falk Kiefer, Georgy Bakalkin, Anita C. Hansson, Falk W. Lohoff, Olli Kärkkäinen, Eloise Kok, Pekka J. Karhunen, Greg T. Sutherland, Consuelo Walss-Bass, Rainer Spanagel, Marcella Rietschel, Dirk A. Moser, Stephanie H. Witt |
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| E-Jahr: | 2024 |
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| Jahr: | February 2024 |
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| Umfang: | 10 S. |
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| Fussnoten: | Online veröffentlicht: 26 January 2024 ; Gesehen am 03.02.2025 |
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| Titel Quelle: | Enthalten in: Alcoholism |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1977 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 48(2024), 2 vom: Feb., Seite 250-259 |
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| ISSN Quelle: | 1530-0277 |
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| Abstract: | Background Alcohol use disorder (AUD) is associated with increased mortality and morbidity risk. A reason for this could be accelerated biological aging, which is strongly influenced by disease processes such as inflammation. As recent studies of AUD show changes in DNA methylation and gene expression in neuroinflammation-related pathways in the brain, biological aging represents a potentially important construct for understanding the adverse effects of substance use disorders. Epigenetic clocks have shown accelerated aging in blood samples from individuals with AUD. However, no systematic evaluation of biological age measures in AUD across different tissues and brain regions has been undertaken. Methods As markers of biological aging (BioAge markers), we assessed Levine's and Horvath's epigenetic clocks, DNA methylation telomere length (DNAmTL), telomere length (TL), and mitochondrial DNA copy number (mtDNAcn) in postmortem brain samples from Brodmann Area 9 (BA9), caudate nucleus, and ventral striatum (N = 63-94), and in whole blood samples (N = 179) of individuals with and without AUD. To evaluate the association between AUD status and BioAge markers, we performed linear regression analyses while adjusting for covariates. Results The majority of BioAge markers were significantly associated with chronological age in all samples. Levine's epigenetic clock and DNAmTL were indicative of accelerated biological aging in AUD in BA9 and whole blood samples, while Horvath's showed the opposite effect in BA9. No significant association of AUD with TL and mtDNAcn was detected. Measured TL and DNAmTL showed only small correlations in blood and none in brain. Conclusions The present study is the first to simultaneously investigate epigenetic clocks, telomere length, and mtDNAcn in postmortem brain and whole blood samples in individuals with AUD. We found evidence for accelerated biological aging in AUD in blood and brain, as measured by Levine's epigenetic clock, and DNAmTL. Additional studies of different tissues from the same individuals are needed to draw valid conclusions about the congruence of biological aging in blood and brain. |
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| DOI: | doi:10.1111/acer.15241 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1111/acer.15241 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/acer.15241 |
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| | DOI: https://doi.org/10.1111/acer.15241 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | alcohol use disorder |
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| | biological aging |
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| | copy numbers of mitochondrial DNA |
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| | epigenetic clocks |
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| | telomere length |
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| K10plus-PPN: | 191616563X |
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| Verknüpfungen: | → Zeitschrift |
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Biological aging markers in blood and brain tissue indicate age acceleration in alcohol use disorder / Zillich, Lea [VerfasserIn]; February 2024 (Online-Ressource)
