Influence of cisplatinum and 5-fluorouracil on the oral mucosa

• Verfasst von: Zöller, Joachim E. [VerfasserIn]
• Verfasst von: Flentje, Michael [VerfasserIn]
• Verfasst von: Born, Ivan Antonio [VerfasserIn]
• Verfasst von: Osswald, Hans [VerfasserIn]
• Titel: Influence of cisplatinum and 5-fluorouracil on the oral mucosa
• Verf.angabe: J. Zöller, M. Flentje, I.A. Born, H. Osswald
• Jahr: 1994
• Umfang: 4 S.
• Fussnoten: Gesehen am 06.02.2025 ; Elektronische Reproduktion der Druck-Ausgabe 15. April 2004
• Titel Quelle: Enthalten in: European journal of cancer. B, Oral oncology
• Ort Quelle: Kidlington : Elsevier Science, 1992
• Jahr Quelle: 1994
• Band/Heft Quelle: 30(1994), 3, Seite 200-203
• ISSN Quelle: 1878-6766
• DOI: doi:10.1016/0964-1955(94)90092-2
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Chemotherapy
• Sach-SW: malignant transformation
• Sach-SW: oral carcinoma
• Sach-SW: second primary tumour
• K10plus-PPN: 191656724X

Abstract

In a prospective study we examined the effect of preoperative chemotherapy with cisplatinum and 5-fluorouracil (5FU) in 40 patients with a carcinoma of the oral cavity. Histopathological grading, cell kinetic and immuno-histochemical parameters of the mucosa were determined at two different locations. Prior to therapy histological dysplasias “close” to the tumour were observed in the mucosa of 75% of the patients. Dysplastic changes of the mucosa “far” from the tumour were also found in more than one third of the patients. Our results show that more advanced dysplasias improve under the influence of preoperative systemic chemotherapy only temporarily. Moreover, new dysplasias which appeared during chemotherapy and persisted after its termination are probably induced.