Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Nußhag, Christian [VerfasserIn]   i
 Uhrig, Josephine [VerfasserIn]   i
 Gruber, Gefion [VerfasserIn]   i
 Schreiber, Pamela [VerfasserIn]   i
 Zeier, Martin [VerfasserIn]   i
 Krautkrämer, Ellen [VerfasserIn]   i
Titel:Glomerular injury is associated with severe courses of orthohantavirus infection
Verf.angabe:Christian Nusshag, Josephine Uhrig, Gefion Gruber, Pamela Schreiber, Martin Zeier and Ellen Krautkrämer
E-Jahr:2024
Jahr:16 August 2024
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 07.02.2025
Titel Quelle:Enthalten in: Pathogens
Ort Quelle:Basel : MDPI, 2012
Jahr Quelle:2024
Band/Heft Quelle:13(2024), 8, Artikel-ID 693, Seite 1-8
ISSN Quelle:2076-0817
Abstract:Hemorrhagic fever with renal syndrome (HFRS) induced by Eurasian pathogenic orthohantaviruses is characterized by acute kidney injury (AKI) with often massive proteinuria. The mechanisms of the organ-specific manifestation are not completely understood. To analyze the role of glomerular and tubular damage in kidney injury induced by HFRS, we measured specific markers in urine samples of patients with acute Puumala virus (PUUV) infection and determined their correlation with disease severity. Levels of α1-microglobulin (α1-MG) and kidney injury molecule 1 (KIM-1), which is expressed by injured tubular epithelial cells, were measured to detect tubular dysfunction and injury. Immunoglobulin G (IgG) and the podocyte specific protein nephrin served as markers for glomerular injury. All four markers were elevated on admission. Markers of glomerular injury, IgG and nephrin, correlated with markers of disease severity such as length of hospitalization, serum creatinine, and proteinuria. In contrast, tubular injury did not correlate with these severity markers. Our results demonstrate that hantavirus infection induces both glomerular and tubular injury early in the clinical course. However, the glomerular dysfunction and podocyte injury seem to contribute directly to disease severity and to play a more central role in HFRS pathogenicity than direct damage to tubular epithelial cells.
DOI:doi:10.3390/pathogens13080693
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/pathogens13080693
 kostenfrei: Volltext: https://www.mdpi.com/2076-0817/13/8/693
 DOI: https://doi.org/10.3390/pathogens13080693
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:acute kidney injury
 AKI
 glomerular injury
 hantavirus
 hemorrhagic fever with renal syndrome
 HFRS
 podocytes
 proteinuria
K10plus-PPN:191663947X
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69302055   QR-Code
zum Seitenanfang