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Status: Bibliographieeintrag

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Verfasst von:Lamadé, Eva [VerfasserIn]   i
 Pedraz-Petrozzi, Bruno [VerfasserIn]   i
 Lindner, Ole [VerfasserIn]   i
 Meininger, Pascal [VerfasserIn]   i
 Coenen, Michaela [VerfasserIn]   i
 Witt, Stephanie [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
 Dukal, Helene [VerfasserIn]   i
 Gilles, Maria [VerfasserIn]   i
 Wudy, Stefan A. [VerfasserIn]   i
 Hellweg, Rainer [VerfasserIn]   i
 Deuschle, Michael [VerfasserIn]   i
Titel:Stress during pregnancy and fetal serum BDNF in cord blood at birth
Verf.angabe:Eva Kathrin Lamadé, Bruno Pedraz-Petrozzi, Ole Lindner, Pascal Meininger, Michaela Coenen, Stephanie H. Witt, Marcella Rietschel, Helene Dukal, Maria Gilles, Stefan A. Wudy, Rainer Hellweg, Michael Deuschle
E-Jahr:2024
Jahr:July 2024
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar: 27. März 2024, Artikelversion: 10. April 2024 ; Gesehen am 10.02.2025
Titel Quelle:Enthalten in: Psychoneuroendocrinology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2024
Band/Heft Quelle:165(2024), Artikel-ID 107035, Seite 1-8
ISSN Quelle:1873-3360
Abstract:Introduction - Adverse environments during pregnancy impact neurodevelopment including cognitive abilities of the developing children. The mediating biological alterations are not fully understood. Maternal stress may impact the neurotrophic regulation of the offspring as early as in utero and at birth. Brain-derived neurotrophic factor (BDNF) is essential for neurodevelopment. Short-term higher levels of BDNF in mice upon stressors associate with lower BDNF later in life, which itself associates with depression in animals and humans. Stress including glucocorticoids may impact BDNF, but there is a lack of data at birth. This study investigated if stress near term associates with fetal BDNF at birth in humans. - Methods - Pregnant women near term who underwent primary cesarean sections (at 38.80±0.64 weeks), were included in this study (n=41). Stress at the end of pregnancy was assessed before the cesarean section by determining maternal depressive symptoms (EDPS), maternal state and trait anxiety (STAI-S and STAI-T), maternal prenatal distress (PDQ), stress over the past month (PSS), prenatal attachment to the offspring (PAI), maternal social support (F-Sozu), maternal early life stress (CTQ), socioeconomic status, and the glucocorticoids cortisol and cortisone (n=40) in amniotic fluid at birth. The association with fetal BDNF was analyzed. Cord blood serum of n=34 newborns at birth was analyzed for BDNF and newborn anthropometrics (weight, length and head circumference per gestational age at birth) were assessed. The association of fetal BDNF with anthropometrics at birth was analyzed. - Results - After a BDNF-outlier (>3SD) was removed, higher fetal BDNF associated significantly with maternal depressive symptoms (r=0.398, p=0.022), with lower socioeconomic status as assessed by the average number of people per room in the household (r=0.526, p=0.002) and with borderline significance with net income per person in the household (r=-0.313, p=0.087) in the bivariate analyses. In multivariable analysis, BDNF stayed positively associated with maternal depressive symptoms (β=0.404, 95% CI [7.057, 306.041], p=0.041) and lower net income per person in the household (β=-0.562, 95% CI [-914.511, −60.523], p=0.027) when controlling for maternal age, maternal pre-pregnancy BMI, fetal sex and gestational age. Fetal BDNF did not associate with newborn anthropometrics with the outlier removed in bivariate analyses or in multivariable analyses when controlling for maternal BMI and fetal sex. - Conclusion - Maternal depressive symptoms and lower socioeconomic status associated with higher fetal BDNF when controlling for confounders. Fetal BDNF did not associate with newborn anthropometrics with the outlier removed. Further studies should investigate how early altered BDNF associate with the development and possibly psychopathology of the offspring.
DOI:doi:10.1016/j.psyneuen.2024.107035
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.psyneuen.2024.107035
 Volltext: https://www.sciencedirect.com/science/article/pii/S0306453024000799
 DOI: https://doi.org/10.1016/j.psyneuen.2024.107035
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cord blood
 Cortisol
 Fetal BDNF
 Pregnancy
 Socioeconomic status
 Stress
K10plus-PPN:1916806848
Verknüpfungen:→ Zeitschrift

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