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Verfasst von:Haas, Rainer [VerfasserIn]   i
 Möhle, Robert [VerfasserIn]   i
 Frühauf, Stefan [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Witt, Barbara Ingeborg [VerfasserIn]   i
 Flentje, Michael [VerfasserIn]   i
 Wannenmacher, Michael [VerfasserIn]   i
 Hunstein, Werner [VerfasserIn]   i
Titel:Patient characteristics associated with successful mobilizing and autografting of peripheral blood progenitor cells in malignant lymphoma
Verf.angabe:Rainer Haas, Robert Möhle, Stefan Frühauf, Hartmut Goldschmidt, Barbara Witt, Michael Flentje, Michael Wannenmacher, Werner Hunstein
E-Jahr:1994
Jahr:15 June 1994
Umfang:8 S.
Fussnoten:Elektronische Reproduktion der Druck-Ausgabe 22. Dezember 2020 ; Gesehen am 11.02.2025
Titel Quelle:Enthalten in: Blood
Ort Quelle:Washington, DC : American Society of Hematology, 1946
Jahr Quelle:1994
Band/Heft Quelle:83(1994), 12, Seite 3787-3794
ISSN Quelle:1528-0020
Abstract:For patients with advanced-stage or poor-prognosis malignant lymphoma, high-dose therapy with peripheral blood progenitor cell (PBPC) support may become a first-line treatment. The duration of severe cytopenia in this setting is inversely related to the number of PBPCs autografted. In a retrospective analysis, we therefore looked for factors influencing the yield of PBPCs in 61 patients (16 with high-grade and 29 with low-/intermediate-grade non-Hodgkin's lymphoma [NHL], and 16 with Hodgkin's disease) who received cytotoxic chemotherapy and filgrastim (R-metHuG-CSF, 300 μg/d; median, 4.2 μg/kg/d; range, 2.7 to 6.6 μg/ kg/d; subcutaneously). Sixteen patients had active disease, while 45 were in partial remission (PR) or complete remission (CR) after conventional therapy. A median of three leukaphereses (range, one to 10) resulted in a median of 5.7 × 106 CD34+ cells/kg (range, 0.03 to 31.1 × 106). Previous cytotoxic chemotherapy and irradiation adversely affected the yield of CD34+ cells. Each cycle of chemotherapy is associated with an average decrease of 0.2 × 106 CD34+ cells/kg per leukapheresis in nonirradiated patients, while large-field radiotherapy reduces the collection efficiency by an average of 1.8 × 106/kg CD34+ cells. The collection efficiency was also significantly lower in patients with Hodgkin's disease. However, except for one, all had been previously irradiated. In contrast, age, sex, disease status, bone marrow involvement during mobilization, and the time since the last chemotherapy or radiotherapy were not significantly related to the collection efficiency. Following high-dose conditioning therapy, 42 patients were autografted with filgrastim-mobilized PBPCs. Hematological recovery (neutrophils ≥0.5 × 109/L and an unsupported platelet count ≥20 × 109/L) within 2 weeks was observed in patients autografted with ≥2.5 × 106 CD34+ cells/kg. In seven patients, the quantity of CD34+ cells reinfused was below this threshold. They required a median of 17 days (range, 11 to 34) and 31 days (range, 13 to 141) for neutrophil and platelet recovery, respectively. K autografting with PBPCs in malignant lymphoma with poor prognosis is being considered, mobilization and harvesting should be planned early after initial diagnosis to avoid exhaustion of hematopoiesis by cumulative toxicity.
DOI:doi:10.1182/blood.V83.12.3787.3787
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1182/blood.V83.12.3787.3787
 Volltext: https://www.sciencedirect.com/science/article/pii/S0006497120788774
 DOI: https://doi.org/10.1182/blood.V83.12.3787.3787
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1916945163
Verknüpfungen:→ Zeitschrift

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