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Verfasst von:Haas, Rainer [VerfasserIn]   i
 Moos, Marion [VerfasserIn]   i
 Karcher, Andreas [VerfasserIn]   i
 Möhle, Robert [VerfasserIn]   i
 Witt, Barbara Ingeborg [VerfasserIn]   i
 Goldschmidt, Hartmut [VerfasserIn]   i
 Frühauf, Stefan [VerfasserIn]   i
 Flentje, Michael [VerfasserIn]   i
 Wannenmacher, Michael [VerfasserIn]   i
 Hunstein, Werner [VerfasserIn]   i
Titel:Sequential high-dose therapy with peripheral-blood progenitor-cell support in low-grade non-Hodgkin's lymphoma.
Verf.angabe:R Haas, M Moos, A Karcher, R Möhle, B Witt, H Goldschmidt, S Frühauf, M Flentje, M Wannenmacher, W Hunstein
E-Jahr:1994
Jahr:August 01, 1994
Umfang:8 S.
Fussnoten:Gesehen am 11.02.2025
Titel Quelle:Enthalten in: Journal of clinical oncology
Ort Quelle:Alexandria, Va. : American Society of Clinical Oncology, 1983
Jahr Quelle:1994
Band/Heft Quelle:12(1994), 8, Seite 1685-1692
ISSN Quelle:1527-7755
Abstract:Purpose - To evaluate the feasibility of a sequential high-dose therapy with peripheral-blood progenitor-cell (PBPC) support in patients with follicular lymphoma. - Patients and Methods - Since July 1991, we have included 30 patients (17 men and 13 women) with a median age of 41 years (range, 26 to 55) in the study. At the time of study entry, 17 patients were in first and six in second or higher remission. Another six patients had relapse of disease and one had tumor progression. PBPC were collected during filgrastim-supported leukocyte recovery following high-dose cytarabine (ara-C)/mitoxantrone (HAM). - Results - A median of two leukaphereses (range, one to seven) resulted in a median of 5.7 x 10(6) CD34+ cells/kg (range, 2.9 to 23.7 x 10(6). A distinct population of B-lymphoid progenitors (CD34+/CD19+) was not detectable in the autografts, and the content of CD19+ B cells was remarkably low, comprising a median of 0.07% of the mononuclear cells. Using the polymerase chain reaction (PCR) assay for the major breakpoint regions (MBR) of the bcl-2/immunoglobulin H (IgH) translocation, 22 patients had autografts positive for the t(14;18) translocation, whereas seven patients had PCR-negative transplants. The autograft of one patient could not be assessed. Following myeloablative therapy, hematologic recovery was rapid without cytokine support. The median times to reach a platelet count > or = 20 x 10(9)/L and neutrophil count > or = 0.5 x 10(9)/L were 11 and 13 days, respectively. Nonhematologic toxicity was moderate. Twenty-nine patients were alive in remission after a median follow-up duration of 6 months (range, 1 to 18). Of 22 patients autografted with t(14;18)-positive harvests, 11 had PCR-detectable cells in bone marrow and/or peripheral blood as long as 16 months posttransplantation. In contrast, six patients became PCR-negative between 3 and 16 months after reinfusion. Follow-up examinations with PCR data for the remaining five patients are not yet available. - Conclusion - Conversion to PCR negativity in patients autografted with PCR-positive harvests suggests that the myeloablative regimen is effective and that any reinfused t(14;18)-positive cells may not be sustained. Because conventional chemotherapy provides no cure, we believe that high-dose therapy including total-body irradiation (TBI) should be explored in these particularly radiosensitive lymphomas.
DOI:doi:10.1200/JCO.1994.12.8.1685
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1200/JCO.1994.12.8.1685
 Volltext: https://ascopubs.org/doi/10.1200/JCO.1994.12.8.1685
 DOI: https://doi.org/10.1200/JCO.1994.12.8.1685
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1917005075
Verknüpfungen:→ Zeitschrift

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