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| Verfasst von: | Masarapu, Yuvarani [VerfasserIn]  |
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| | Cekanaviciute, Egle [VerfasserIn] |
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| | Andrusivova, Zaneta [VerfasserIn] |
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| | Westholm, Jakub O. [VerfasserIn] |
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| | Björklund, Åsa [VerfasserIn] |
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| | Fallegger, Robin [VerfasserIn] |
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| | Badia-i-Mompel, Pau [VerfasserIn] |
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| | Boyko, Valery [VerfasserIn] |
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| | Vasisht, Shubha [VerfasserIn] |
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| | Saravia-Butler, Amanda [VerfasserIn] |
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| | Gebre, Samrawit [VerfasserIn] |
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| | Lázár, Enikő [VerfasserIn] |
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| | Graziano, Marta [VerfasserIn] |
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| | Frapard, Solène [VerfasserIn] |
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| | Hinshaw, Robert G. [VerfasserIn] |
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| | Bergmann, Olaf Ingmar [VerfasserIn] |
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| | Taylor, Deanne M. [VerfasserIn] |
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| | Wallace, Douglas C. [VerfasserIn] |
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| | Sylvén, Christer [VerfasserIn] |
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| | Meletis, Konstantinos [VerfasserIn] |
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| | Sáez Rodríguez, Julio [VerfasserIn] |
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| | Galazka, Jonathan M. [VerfasserIn] |
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| | Costes, Sylvain V. [VerfasserIn] |
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| | Giacomello, Stefania [VerfasserIn] |
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| Titel: | Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice |
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| Verf.angabe: | Yuvarani Masarapu, Egle Cekanaviciute, Zaneta Andrusivova, Jakub O. Westholm, Åsa Björklund, Robin Fallegger, Pau Badia-i-Mompel, Valery Boyko, Shubha Vasisht, Amanda Saravia-Butler, Samrawit Gebre, Enikő Lázár, Marta Graziano, Solène Frapard, Robert G. Hinshaw, Olaf Bergmann, Deanne M. Taylor, Douglas C. Wallace, Christer Sylvén, Konstantinos Meletis, Julio Saez-Rodriguez, Jonathan M. Galazka, Sylvain V. Costes & Stefania Giacomello |
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| E-Jahr: | 2024 |
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| Jahr: | 11 June 2024 |
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| Umfang: | 14 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 13.02.2025 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 4778, Seite 1-14 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Impairment of the central nervous system (CNS) poses a significant health risk for astronauts during long-duration space missions. In this study, we employed an innovative approach by integrating single-cell multiomics (transcriptomics and chromatin accessibility) with spatial transcriptomics to elucidate the impact of spaceflight on the mouse brain in female mice. Our comparative analysis between ground control and spaceflight-exposed animals revealed significant alterations in essential brain processes including neurogenesis, synaptogenesis and synaptic transmission, particularly affecting the cortex, hippocampus, striatum and neuroendocrine structures. Additionally, we observed astrocyte activation and signs of immune dysfunction. At the pathway level, some spaceflight-induced changes in the brain exhibit similarities with neurodegenerative disorders, marked by oxidative stress and protein misfolding. Our integrated spatial multiomics approach serves as a stepping stone towards understanding spaceflight-induced CNS impairments at the level of individual brain regions and cell types, and provides a basis for comparison in future spaceflight studies. For broader scientific impact, all datasets from this study are available through an interactive data portal, as well as the National Aeronautics and Space Administration (NASA) Open Science Data Repository (OSDR). |
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| DOI: | doi:10.1038/s41467-024-48916-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-024-48916-8 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-024-48916-8 |
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| | DOI: https://doi.org/10.1038/s41467-024-48916-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Computational neuroscience |
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| | Genetics of the nervous system |
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| | Molecular neuroscience |
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| K10plus-PPN: | 1917199252 |
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| Verknüpfungen: | → Zeitschrift |
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Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice / Masarapu, Yuvarani [VerfasserIn]; 11 June 2024 (Online-Ressource)
