Intra- and inter-reader reproducibility in quantitative coronary plaque analysis on coronary computed tomography angiography

• Verfasst von: Quintana, Raymundo [VerfasserIn]
• Verfasst von: Knebel Doeberitz, Philipp L. von [VerfasserIn]
• Verfasst von: Vatsa, Nishant [VerfasserIn]
• Verfasst von: Liu, Chang [VerfasserIn]
• Verfasst von: Ko, Yi-An [VerfasserIn]
• Verfasst von: De Cecco, Carlo N. [VerfasserIn]
• Verfasst von: van Assen, Marly [VerfasserIn]
• Verfasst von: Quyyumi, Arshed A. [VerfasserIn]
• Titel: Intra- and inter-reader reproducibility in quantitative coronary plaque analysis on coronary computed tomography angiography
• Verf.angabe: Raymundo A. Quintana, MD, Philipp von Knebel Doeberitz, MD, Nishant Vatsa, MD, Chang Liu, MPH, Yi-An Ko, PhD, Carlo N. De Cecco, MD, Marly van Assen, PhD, Arshed A. Quyyumi, MD
• E-Jahr: 2024
• Jahr: 28 April 2024
• Umfang: 7 S.
• Fussnoten: Gesehen am 14.02.2025
• Titel Quelle: Enthalten in: Current problems in cardiology
• Ort Quelle: Chicago, Ill. : Yearbook Medical Publ., 1976
• Jahr Quelle: 2024
• Band/Heft Quelle: 49(2024), 7 vom: Juli, Artikel-ID 102585, Seite 1-7
• ISSN Quelle: 1535-6280
• DOI: doi:10.1016/j.cpcardiol.2024.102585
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Bland-Altman plot
• Sach-SW: Computed Tomography Angiography
• Sach-SW: Computerized tomography
• Sach-SW: Coronary Angiography
• Sach-SW: Coronary artery disease
• Sach-SW: Coronary Artery Disease
• Sach-SW: Coronary Vessels
• Sach-SW: Female
• Sach-SW: Humans
• Sach-SW: Inter-reader
• Sach-SW: Intra-reader reproducibility
• Sach-SW: Male
• Sach-SW: Middle Aged
• Sach-SW: Observer Variation
• Sach-SW: Plaque burden
• Sach-SW: Plaque, Atherosclerotic
• Sach-SW: Reproducibility of Results
• K10plus-PPN: 1917300891

Abstract

PURPOSE: Coronary artery plaque burden, low attenuation non-calcified plaque (LAP), and pericoronary adipose tissue (PCAT) on coronary CT angiography (CCTA), have been linked to future cardiac events. The purpose of this study was to evaluate intra- and inter reader reproducibility in the quantification of coronary plaque burden and its characteristics using an artificial intelligence-enhanced semi-automated software. - MATERIALS AND METHODS: A total of 10 women and 6 men, aged 52 (IQR 49-58) underwent CCTA using a Siemens Somatom Force, Somatom Definition AS and Somatom Definition Flash scanners. Two expert readers utilized dedicated semi-automatic software (vascuCAP, Elucid Bioimaging, Wenham, MA) to assess calcified plaque, low attenuation plaque and PCAT. Readers were blinded to all clinical information and repeated their analysis at 6 weeks in random order to minimize recall bias. Data analysis was performed on the right and left coronary arteries. Intra- and inter-reader reproducibility was compared using Pearson correlation coefficient, while absolute values between analyses and readers were compared with paired non-parametric tests. This is a sub-study of the Specialized Center of Research Excellence (SCORE) clinical trial (5U54AG062334). - RESULTS: A total of 64 vessels from 16 patients were analyzed. Intra-reader Pearson correlation coefficients for calcified plaque volume, LAP volume and PCAT volumes were 0.96, 0.99 and 0.92 for reader 1 and 0.94, 0.94 and 0.95 for reader 2, respectively, (all p < 0.0001). Inter-reader Pearson correlation coefficients for calcified plaque volume, LAP and PCAT volumes were 0.92, 0.96 and 0.78, and 0.99, 0.99 and 0.93 on the second analyses, all had a p value <0.0001. There was no significant bias on the corresponding Bland-Altman analyses. - CONCLUSION: Volume measurement of coronary plaque burden and PCAT volume can be performed with high intra- and inter-reader agreement.