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Verfasst von:Rahbari, Nuh Nabi [VerfasserIn]   i
 Biondo, Sebastiano [VerfasserIn]   i
 Frago, Ricardo [VerfasserIn]   i
 Feißt, Manuel [VerfasserIn]   i
 Kreisler, Esther [VerfasserIn]   i
 Rossion, Inga [VerfasserIn]   i
 Serrano, Monica [VerfasserIn]   i
 Jäger, Dirk [VerfasserIn]   i
 Lehmann, Monika [VerfasserIn]   i
 Sommer, Florian [VerfasserIn]   i
 Dignass, Axel [VerfasserIn]   i
 Bolling, Claus [VerfasserIn]   i
 Vogel, Ilka [VerfasserIn]   i
 Bork, Ulrich [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Folprecht, Gunnar [VerfasserIn]   i
 Kieser, Meinhard [VerfasserIn]   i
 Lordick, Florian [VerfasserIn]   i
 Weitz, Jürgen [VerfasserIn]   i
Titel:Primary tumor resection before systemic therapy in patients with colon cancer and unresectable metastases
Titelzusatz:combined results of the SYNCHRONOUS and CCRe-IV trials
Verf.angabe:Nuh N. Rahbari, MD; Sebastiano Biondo, MD; Ricardo Frago, MD; Manuel Feißt, PhD; Esther Kreisler, MD; Inga Rossion, MD; Monica Serrano, MD; Dirk Jäger, MD; Monika Lehmann, PhD; Florian Sommer, MD; Axel Dignass, MD; Claus Bolling, MD; Ilka Vogel, MD; Ulrich Bork, MD; Markus W. Büchler, MD; Gunnar Folprecht, MD; Meinhard Kieser, PhD; Florian Lordick, MD; and Jürgen Weitz, MD, MSc; on behalf of the SYNCHRONOUS and CCRe-IV Trial Groups
E-Jahr:2024
Jahr:February 27, 2024
Umfang:13 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 14.02.2025
Titel Quelle:Enthalten in: Journal of clinical oncology
Ort Quelle:Alexandria, Va. : American Society of Clinical Oncology, 1983
Jahr Quelle:2024
Band/Heft Quelle:42(2024), 13, Seite 1531-1541, [2]
ISSN Quelle:1527-7755
Abstract:Purpose - Chemotherapy is established as primary treatment in patients with stage IV colorectal cancer and unresectable metastases. Data from nonrandomized clinical trials have fueled persistent uncertainty if primary tumor resection (PTR) before chemotherapy prolongs survival. We investigated the prognostic value of PTR in patients with newly diagnosed stage IV colon cancer who were not amenable to curative treatment. - Patients and Methods - Patients enrolled in the multicenter, randomized SYNCHRONOUS and CCRe-IV trials were included in the analysis. Patients with colon cancer with synchronous unresectable metastases were randomly assigned at 100 sites in Austria, Germany, and Spain to undergo PTR or up-front chemotherapy (No PTR group). The chemotherapy regimen was left at discretion of the local team. Patients with tumor-related symptoms, inability to tolerate surgery and/or systemic chemotherapy, and history of another cancer were excluded. The primary end point was overall survival (OS), and the analyses were performed with intention-to-treat. - Results - A total of 393 patients were randomly assigned to undergo PTR (n = 187) or no PTR (n = 206) between November 2011 and March 2017. Chemotherapy was not administered to 6.4% in the No PTR group and 24.1% in the PTR group. The median follow-up time was 36.7 months (95% CI, 36.6 to 37.3). The median OS was 16.7 months (95% CI, 13.2 to 19.2) in the PTR group and 18.6 months (95% CI, 16.2 to 22.3) in the No PTR group (P = .191). Comparable OS between the study groups was further confirmed on multivariate analysis (hazard ratio, 0.944 [95% CI, 0.738 to 1.209], P = .65) and across all subgroups. Patients with serious adverse events were more common in the No PTR group (10.2% v 18.0%; P = .027). - Conclusion - Among patients with colon cancer and synchronous unresectable metastases, PTR before systemic chemotherapy was not associated with prolonged OS.
DOI:doi:10.1200/JCO.23.01540
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1200/JCO.23.01540
 Volltext: https://ascopubs.org/doi/10.1200/JCO.23.01540
 DOI: https://doi.org/10.1200/JCO.23.01540
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1917314469
Verknüpfungen:→ Zeitschrift

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