The influence of contrast media on calcium-based imaging of the spine in dual-layer CT

• Verfasst von: Rahn, Stefanie [VerfasserIn]
• Verfasst von: Skornitzke, Stephan [VerfasserIn]
• Verfasst von: Melzig, Claudius [VerfasserIn]
• Verfasst von: Reiner, Tobias [VerfasserIn]
• Verfasst von: Stiller, Wolfram [VerfasserIn]
• Verfasst von: Heußel, Claus Peter [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Weber, Tim [VerfasserIn]
• Verfasst von: Do, Thuy [VerfasserIn]
• Titel: The influence of contrast media on calcium-based imaging of the spine in dual-layer CT
• Verf.angabe: S. Rahn, S. Skornitzke, C. Melzig, T. Reiner, W. Stiller, C.P. Heussel, H.U. Kauczor, T.F. Weber & T.D. Do
• E-Jahr: 2024
• Jahr: 14 August 2024
• Umfang: 10 S.
• Fussnoten: Gesehen am 17.02.2025
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Springer Nature, 2011
• Jahr Quelle: 2024
• Band/Heft Quelle: 14(2024), Artikel-ID 18898, Seite 1-10
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-024-69743-3
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cancer
• Sach-SW: Clinical trials
• Sach-SW: Endocrine system and metabolic diseases
• K10plus-PPN: 1917373694

Abstract

This study aimed to evaluate the impact of contrast media application on CT attenuation of the bone using a novel calcium-only imaging technique (VCa) from dual-layer spectral detector CT (DLCT), which enables CT-based bone mineral density measurement unimpeded by soft tissue components. For this, true non-contrast (TNC) and venous phase images (VP) of n = 97 patients were acquired. CT attenuation of the first lumbar vertebra (L1) was measured in TNC-VCa, VP-VCa, and in virtual non-contrast images (VNC). CT attenuation was significantly higher in VP-VCa than in TNC-VCa (p < 0.001), although regression analyses revealed a strong linear association between these measures (R2 = 0.84). A statistical model for the prediction of TNC-VCa CT attenuation was established (TNC-VCa[HU] = − 6.81 + 0.87 × VP-VCa[HU]-0.55 × body weight[kg]) and yielded good agreement between observed and predicted values. Furthermore, a L1 CT attenuation threshold of 293 HU in VP-VCa showed a sensitivity of 90% and a specificity of 96% for detecting osteoporosis. The application of contrast media leads to an overestimation of L1 CT attenuation in VCa. However, CT attenuation values from VP-VCa can be used within CT-based opportunistic osteoporosis screening eighter by applying a separate threshold of 293 HU or by converting measured data to TNC-VCa CT attenuation with the given regression equation.