Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Sid Ahmed, Samy [VerfasserIn]  |
| Bajak, Kathrin [VerfasserIn]  |
| Fackler, Oliver Till [VerfasserIn]  |
Titel: | Beyond impairment of virion infectivity |
Titelzusatz: | new activities of the Anti-HIV host cell factor SERINC5 |
Verf.angabe: | Samy Sid Ahmed, Kathrin Bajak, and Oliver T. Fackler |
E-Jahr: | 2024 |
Jahr: | 12 February 2024 |
Umfang: | 13 S. |
Illustrationen: | Illustrationen |
Fussnoten: | Gesehen am 18.02.2025 ; Titel des special issue: "Research on herpes virus fusion and entry" |
Titel Quelle: | Enthalten in: Viruses |
Ort Quelle: | Basel : MDPI, 2009 |
Jahr Quelle: | 2024 |
Band/Heft Quelle: | 16(2024), 2, special issue, Artikel-ID 284, Seite 284-1-284-13 |
ISSN Quelle: | 1999-4915 |
Abstract: | Members of the serine incorporator (SERINC) protein family exert broad antiviral activity, and many viruses encode SERINC antagonists to circumvent these restrictions. Significant new insight was recently gained into the mechanisms that mediate restriction and antagonism. In this review, we summarize our current understanding of the mode of action and relevance of SERINC proteins in HIV-1 infection. Particular focus will be placed on recent findings that provided important new mechanistic insights into the restriction of HIV-1 virion infectivity, including the discovery of SERINC’s lipid scramblase activity and its antagonism by the HIV-1 pathogenesis factor Nef. We also discuss the identification and implications of several additional antiviral activities by which SERINC proteins enhance pro-inflammatory signaling and reduce viral gene expression in myeloid cells. SERINC proteins emerge as versatile and multifunctional regulators of cell-intrinsic immunity against HIV-1 infection. |
DOI: | doi:10.3390/v16020284 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/v16020284 |
| kostenfrei: Volltext: https://www.mdpi.com/1999-4915/16/2/284 |
| DOI: https://doi.org/10.3390/v16020284 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | HIV-1 |
| innate immunity |
| lipid asymmetry |
| restriction factor |
| SERINC5 |
K10plus-PPN: | 1917438796 |
Verknüpfungen: | → Zeitschrift |
Beyond impairment of virion infectivity / Sid Ahmed, Samy [VerfasserIn]; 12 February 2024 (Online-Ressource)
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