Potential role of Vitamin D in immune response in patients with viral hepatitis

• Verfasst von: Gerhards, Catharina [VerfasserIn]
• Verfasst von: Teufel, Andreas [VerfasserIn]
• Verfasst von: Gerigk, Marlis [VerfasserIn]
• Verfasst von: French, Michael [VerfasserIn]
• Verfasst von: Antoni, Christoph Helmer [VerfasserIn]
• Verfasst von: Ebert, Matthias [VerfasserIn]
• Verfasst von: Neumaier, Michael [VerfasserIn]
• Verfasst von: Evliyaoglu, Osman [VerfasserIn]
• Titel: Potential role of Vitamin D in immune response in patients with viral hepatitis
• Titelzusatz: applied nutritional investigation
• Verf.angabe: Catharina Gerhards, Andreas Teufel, Marlis Gerigk, Michael French, Christoph Antoni, Matthias Ebert, Michael Neumaier, Osman Evliyaoglu
• E-Jahr: 2024
• Jahr: August 2024
• Umfang: 8 S.
• Fussnoten: Online verfügbar: 30. März 2024, Artikelversion: 25. April 2024 ; Gesehen am 18.02.2025
• Titel Quelle: Enthalten in: Nutrition
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1996
• Jahr Quelle: 2024
• Band/Heft Quelle: 124(2024) vom: Aug., Artikel-ID 112447, Seite 1-8
• ISSN Quelle: 1873-1244
• DOI: doi:10.1016/j.nut.2024.112447
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: B cell, Anti-HBs antibody
• Sach-SW: Chronic HBV infection
• Sach-SW: Hepatitis B virus
• Sach-SW: T cell
• Sach-SW: Vitamin D
• K10plus-PPN: 1917456751

Abstract

Background - To study the relationship of Vitamin D with innate and adaptive immune response parameters in chronic hepatitis B and C patients. - Methods - The laboratory data between January 1, 2013 and February 1, 2023, for patients with chronic hepatitis B (CHB), and chronic hepatitis C (CHC) were extracted. Serum 25-hydroxyl vitamin D, hepatitis B virus serological markers, complements, and subsets of T lymphocytes were determined. Study cohorts were divided into groups based on serum 25-hydroxyl vitamin D levels with further evaluation of laboratory data. - Results - In CHB and CHC patients the percentage of CD4+ T lymphocytes and the CD4+/CD8+ ratio significantly decreased (P < 0.05), but the percentage of CD8+ increased (P < 0.05) compared to the control group. In CHB patients Vitamin D decrease was significant (P < 0.001) but not in CHC patients. Vitamin D showed a moderate negative influence on the CD8 cell count in CHB patients. The positive ratio of HBV DNA and HBsAg decreased with increasing serum vitamin D levels. The vitamin D deficient group showed significantly lower antibody production compared to the normal group, and exhibited significantly decreased CD4 numbers and increased CD8 numbers (P < 0.05 and P < 0.001, respectively), while the CD4/CD8 ratio was also significantly decreased in the insufficiency group (P < 0.001). Complement C3 levels were not associated with CD4 and CD8, but had an inverse relation with Vitamin D. Vitamin D levels were significantly associated with complement C3, CD8+, CD4+, CD19+ cells, and HBV DNA levels. - Conclusions - Vitamin D may be a modulator of immune function not only via CD8+ and CD4+ cells but also via CD19+ cells in the course of chronic HBV infection. The negative relationship between vitamin D and complement C3 needs elucidation. Moreover, the increased proportion of B cells and decreased CD4+ cells in Vitamin D deficiency disrupt the immune response against HBV since the expected antibody response was not obtained despite the increase in B cell ratio. This indicates an influence of CD4+ cells for B cell functionality. In summary, sufficient levels of Vitamin D may lead to a sustained virological response that is debatable by artificially correcting the deficiency.