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| Verfasst von: | Malagola, Ermanno [VerfasserIn]  |
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| | Vasciaveo, Alessandro [VerfasserIn] |
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| | Ochiai, Yosuke [VerfasserIn] |
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| | Kim, Woosook [VerfasserIn] |
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| | Zheng, Biyun [VerfasserIn] |
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| | Zanella, Luca [VerfasserIn] |
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| | Wang, Alexander L. E. [VerfasserIn] |
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| | Middelhoff, Moritz [VerfasserIn] |
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| | Nienhüser, Henrik [VerfasserIn] |
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| | Deng, Lu [VerfasserIn] |
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| | Wu, Feijing [VerfasserIn] |
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| | Waterbury, Quin T. [VerfasserIn] |
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| | Belin, Bryana [VerfasserIn] |
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| | LaBella, Jonathan [VerfasserIn] |
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| | Zamechek, Leah B. [VerfasserIn] |
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| | Wong, Melissa H. [VerfasserIn] |
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| | Li, Linheng [VerfasserIn] |
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| | Guha, Chandan [VerfasserIn] |
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| | Cheng, Chia-Wei [VerfasserIn] |
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| | Yan, Kelley S. [VerfasserIn] |
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| | Califano, Andrea [VerfasserIn] |
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| | Wang, Timothy C. [VerfasserIn] |
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| Titel: | Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury |
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| Verf.angabe: | Ermanno Malagola, Alessandro Vasciaveo, Yosuke Ochiai, Woosook Kim, Biyun Zheng, Luca Zanella, Alexander L. E. Wang, Moritz Middelhoff, Henrik Nienhüser, Lu Deng, Feijing Wu, Quin T. Waterbury, Bryana Belin, Jonathan LaBella, Leah B. Zamechek, Melissa H. Wong, Linheng Li, Chandan Guha, Chia-Wei Cheng, Kelley S. Yan, Andrea Califano, and Timothy C. Wang |
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| E-Jahr: | 2024 |
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| Jahr: | 6 June 2024 |
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| Umfang: | 33 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 18.02.2025 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 187(2024), 12 vom: Juni, Seite 3056-3071.e17 |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | The currently accepted intestinal epithelial cell organization model proposes that Lgr5+ crypt-base columnar (CBC) cells represent the sole intestinal stem cell (ISC) compartment. However, previous studies have indicated that Lgr5+ cells are dispensable for intestinal regeneration, leading to two major hypotheses: one favoring the presence of a quiescent reserve ISC and the other calling for differentiated cell plasticity. To investigate these possibilities, we studied crypt epithelial cells in an unbiased fashion via high-resolution single-cell profiling. These studies, combined with in vivo lineage tracing, show that Lgr5 is not a specific ISC marker and that stemness potential exists beyond the crypt base and resides in the isthmus region, where undifferentiated cells participate in intestinal homeostasis and regeneration following irradiation (IR) injury. Our results provide an alternative model of intestinal epithelial cell organization, suggesting that stemness potential is not restricted to CBC cells, and neither de-differentiation nor reserve ISC are drivers of intestinal regeneration. |
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| DOI: | doi:10.1016/j.cell.2024.05.004 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cell.2024.05.004 |
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| | DOI: https://doi.org/10.1016/j.cell.2024.05.004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adult stem cells |
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| | Animals |
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| | Cell Differentiation |
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| | cell potency |
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| | Epithelial Cells |
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| | epithelial stem cells |
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| | Homeostasis |
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| | Intestinal Mucosa |
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| | intestinal stem cells |
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| | intestine |
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| | Intestines |
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| | Male |
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| | Mice |
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| | Mice, Inbred C57BL |
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| | plasticity |
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| | Receptors, G-Protein-Coupled |
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| | regeneration |
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| | Regeneration |
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| | regulatory network analysis |
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| | single cell |
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| | Single-Cell Analysis |
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| | Stem Cells |
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| | stemness signature |
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| K10plus-PPN: | 1917477546 |
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| Verknüpfungen: | → Zeitschrift |
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Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury / Malagola, Ermanno [VerfasserIn]; 6 June 2024 (Online-Ressource)
