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| Verfasst von: | Röhrich, Manuel [VerfasserIn]  |
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| | Daum, Johanna [VerfasserIn] |
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| | Gutjahr, Ewgenija [VerfasserIn] |
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| | Spektor, Anna-Maria [VerfasserIn] |
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| | Glatting, Frederik M. [VerfasserIn] |
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| | Sahin, Yasemin [VerfasserIn] |
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| | Buchholz, Hans Georg [VerfasserIn] |
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| | Hoppner, Jorge [VerfasserIn] |
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| | Schroeter, Cathrin [VerfasserIn] |
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| | Mavriopoulou, Eleni [VerfasserIn] |
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| | Schlamp, Kai [VerfasserIn] |
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| | Grott, Matthias [VerfasserIn] |
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| | Eichhorn, Florian [VerfasserIn] |
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| | Heußel, Claus Peter [VerfasserIn] |
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| | Kauczor, Hans-Ulrich [VerfasserIn] |
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| | Kreuter, Michael [VerfasserIn] |
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| | Giesel, Frederik L. [VerfasserIn] |
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| | Schreckenberger, Mathias [VerfasserIn] |
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| | Winter, Hauke [VerfasserIn] |
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| | Haberkorn, Uwe [VerfasserIn] |
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| Titel: | Diagnostic potential of supplemental static and dynamic 68Ga-FAPI-46 PET for primary 18F-FDG-negative pulmonary lesions |
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| Verf.angabe: | Manuel Röhrich, Johanna Daum, Ewgenija Gutjahr, Anna-Maria Spektor, Frederik M. Glatting, Yasemin Aylin Sahin, Hans Georg Buchholz, Jorge Hoppner, Cathrin Schroeter, Eleni Mavriopoulou, Kai Schlamp, Matthias Grott, Florian Eichhorn, Claus Peter Heußel, Hans Ulrich Kauczor, Michael Kreuter, Frederik Giesel, Mathias Schreckenberger, Hauke Winter and Uwe Haberkorn |
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| E-Jahr: | 2024 |
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| Jahr: | April 11, 2024 |
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| Umfang: | 8 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Im Titel sind "68" und "18" hochgestellt ; Gesehen am 18.02.2025 |
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| Titel Quelle: | Enthalten in: Journal of nuclear medicine |
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| Ort Quelle: | New York, NY : Soc., 1964 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 65(2024), 6 vom: Apr., Seite 872-879 |
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| ISSN Quelle: | 2159-662X |
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| | 1535-5667 |
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| Abstract: | PET using 68Ga-labeled fibroblast activation protein (FAP) inhibitors (FAPIs) holds high potential for diagnostic imaging of various malignancies, including lung cancer (LC). However, 18F-FDG PET is still the clinical gold standard for LC imaging. Several subtypes of LC, especially lepidic LC, are frequently 18F-FDG PET-negative, which markedly hampers the assessment of single pulmonary lesions suggestive of LC. Here, we evaluated the diagnostic potential of static and dynamic 68Ga-FAPI-46 PET in the 18F-FDG-negative pulmonary lesions of 19 patients who underwent surgery or biopsy for histologic diagnosis after PET imaging. For target validation, FAP expression in lepidic LC was confirmed by FAP immunohistochemistry. Methods: Hematoxylin and eosin staining and FAP immunohistochemistry of 24 tissue sections of lepidic LC from the local tissue bank were performed and analyzed visually. Clinically, 19 patients underwent static and dynamic 68Ga-FAPI-46 PET in addition to 18F-FDG PET based on individual clinical indications. Static PET data of both examinations were analyzed by determining SUVmax, SUVmean, and tumor-to-background ratio (TBR) against the blood pool, as well as relative parameters (68Ga-FAPI-46 in relation to18F-FDG), of histologically confirmed LC and benign lesions. Time-activity curves and dynamic parameters (time to peak, slope, k 1, k 2, k 3, and k 4) were extracted from dynamic 68Ga-FAPI-46 PET data. The sensitivity and specificity of all parameters were analyzed by calculating receiver-operating-characteristic curves. Results: FAP immunohistochemistry confirmed the presence of strongly FAP-positive cancer-associated fibroblasts in lepidic LC. LC showed markedly elevated 68Ga-FAPI-46 uptake, higher TBRs, and higher 68Ga-FAPI-46-to-18F-FDG ratios for all parameters than did benign pulmonary lesions. Dynamic imaging analysis revealed differential time-activity curves for LC and benign pulmonary lesions: initially increasing time-activity curves with a decent slope were typical of LC, and steadily decreasing time-activity curve indicated benign pulmonary lesions, as was reflected by a significantly increased time to peak and significantly smaller absolute values of the slope for LC. Relative 68Ga-FAPI-46-to-18F-FDG ratios regarding SUVmax and TBR showed the highest sensitivity and specificity for the discrimination of LC from benign pulmonary lesions. Conclusion: 68Ga-FAPI-46 PET is a powerful new tool for the assessment of single 18F-FDG-negative pulmonary lesions and may optimize patient stratification in this clinical setting. |
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| DOI: | doi:10.2967/jnumed.123.267103 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.2967/jnumed.123.267103 |
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| | DOI: https://doi.org/10.2967/jnumed.123.267103 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Aged |
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| | Aged, 80 and over |
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| | FAPI |
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| | Female |
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| | fibroblast activation protein |
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| | Fluorodeoxyglucose F18 |
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| | Humans |
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| | lung cancer |
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| | Lung Neoplasms |
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| | Male |
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| | Middle Aged |
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| | PET |
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| | Positron-Emission Tomography |
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| | pulmonary lesions |
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| | Quinolines |
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| | Radiopharmaceuticals |
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| K10plus-PPN: | 1917479581 |
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| Verknüpfungen: | → Zeitschrift |
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Diagnostic potential of supplemental static and dynamic 68Ga-FAPI-46 PET for primary 18F-FDG-negative pulmonary lesions / Röhrich, Manuel [VerfasserIn]; April 11, 2024 (Online-Ressource)
