Vitamin D level and low-energy fracture risk in children and adolescents

• Verfasst von: Assaf, Elio [VerfasserIn]
• Verfasst von: Nicolas, Georges [VerfasserIn]
• Verfasst von: Hoyek, Fadi [VerfasserIn]
• Verfasst von: Abi Fares, Georges [VerfasserIn]
• Verfasst von: Lahoud, Jean Claude [VerfasserIn]
• Verfasst von: Hajj, Rabih [VerfasserIn]
• Verfasst von: Mohs, Elisabeth [VerfasserIn]
• Verfasst von: Dally, Franz-J. [VerfasserIn]
• Verfasst von: Hetjens, Svetlana [VerfasserIn]
• Verfasst von: Gravius, Sascha [VerfasserIn]
• Verfasst von: Darwich, Ali [VerfasserIn]
• Titel: Vitamin D level and low-energy fracture risk in children and adolescents
• Titelzusatz: a population-based case-control study of 45 cases
• Verf.angabe: Elio Assaf, Georges Nicolas, Fadi Hoyek, Georges Abi Fares, Jean Claude Lahoud, Rabih Hajj, Elisabeth Mohs, Franz-J. Dally, Svetlana Hetjens, Sascha Gravius, Ali Darwich
• E-Jahr: 2024
• Jahr: July 2024
• Umfang: 7 S.
• Fussnoten: Gesehen am 20.02.2025
• Titel Quelle: Enthalten in: Journal of pediatric orthopaedics
• Ort Quelle: Philadelphia, Pa. : Lippincott Williams & Wilkins, 1992
• Jahr Quelle: 2024
• Band/Heft Quelle: 33(2024), 4, Seite 392-398
• ISSN Quelle: 1473-5865
• DOI: doi:10.1097/BPB.0000000000001061
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1917656254

Abstract

The objective of this study is to document the rate of vitamin D deficiency and insufficiency among children with low-energy fractures and compare it to fracture-free control group. We included all children under 15 years presenting to the emergency department with low-energy fractures; controls were children without history of fractures from the outpatient department. Conventional X-ray and laboratory blood tests were performed. Vitamin D deficiency was defined as serum level ≤20 ng/ml, and the mean values were compared through two-sample t-tests. The influence of vitamin D on the fractures was defined using Chi-square test, significance with P-value < 0.05. The relationships between variables and odds of fracture occurrence were examined using logistic regression models. The final sample included 37 cases (30 males, 7 females, 7.4 ± 3.7 years) and 70 control individuals (42 males, 28 females, 7.8 ± 4.6 years) without significant differences regarding age, sex, and month of inclusion. Children with fractures had lower levels of vitamin D (21.87 ± 8.40 ng/ml vs. 25.89 ± 7.62 ng/ml) (P = 0.01). Vitamin D played a protective role against low-energy fractures (OR, 1.08; 95% CI, 1.01-1.14; P = 0.02), boys showed three times greater fracture risk than girls (OR, 3.00; 95% CI, 1.12-8.07; P = 0.03). Finally, vitamin D deficiency correlated with almost five times increased risk of pediatric low-energy fractures (OR, 4.63; 95% CI, 1.92-11.18; P = 0.001). This is the first MENA study establishing a relation between vitamin D deficiency and low-energy fractures among children and adolescents. The findings show the protective role of vitamin D on the pediatric bone and may help physicians preventing morbidity on children and costs on their families and the socioeconomic health system.