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Status: Bibliographieeintrag

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Verfasst von:Gerke, Carolin [VerfasserIn]   i
 Bauersfeld, Liane [VerfasserIn]   i
 Schirmeister, Ivo [VerfasserIn]   i
 Mireisz, Chiara Noemi-Marie [VerfasserIn]   i
 Oberhardt, Valerie [VerfasserIn]   i
 Mery, Lea [VerfasserIn]   i
 Wu, Di [VerfasserIn]   i
 Jürges, Christopher Sebastian [VerfasserIn]   i
 Spaapen, Robbert M. [VerfasserIn]   i
 Mussolino, Claudio [VerfasserIn]   i
 Le, Vu Thuy Khanh [VerfasserIn]   i
 Trilling, Mirko [VerfasserIn]   i
 Dölken, Lars [VerfasserIn]   i
 Paster, Wolfgang [VerfasserIn]   i
 Erhard, Florian [VerfasserIn]   i
 Hofmann, Maike [VerfasserIn]   i
 Schlosser, Andreas [VerfasserIn]   i
 Hengel, Hartmut [VerfasserIn]   i
 Momburg, Frank [VerfasserIn]   i
 Halenius, Anne [VerfasserIn]   i
Titel:Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning
Verf.angabe:Carolin Gerke, Liane Bauersfeld, Ivo Schirmeister, Chiara Noemi-Marie Mireisz, Valerie Oberhardt, Lea Mery, Di Wu, Christopher Sebastian Jürges, Robbert M. Spaapen, Claudio Mussolino, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Lars Dölken, Wolfgang Paster, Florian Erhard, Maike Hofmann, Andreas Schlosser, Hartmut Hengel, Frank Momburg, Anne Halenius
E-Jahr:2024
Jahr:20 June, 2024
Umfang:29 S.
Illustrationen:Illustrationen
Fussnoten:Gesehen am 20.02.2025
Titel Quelle:Enthalten in: eLife
Ort Quelle:Cambridge : eLife Sciences Publications, 2012
Jahr Quelle:2024
Band/Heft Quelle:13(2024) vom: Juni, Artikel-ID e85560, Seite 1-29
ISSN Quelle:2050-084X
Abstract:Human leucocyte antigen class I (HLA-I) molecules play a central role for both NK and T-cell responses that prevent serious human cytomegalovirus (HCMV) disease. To create opportunities for viral spread, several HCMV-encoded immunoevasins employ diverse strategies to target HLA-I. Among these, the glycoprotein US10 is so far insufficiently studied. While it was reported that US10 interferes with HLA-G expression, its ability to manipulate classical HLA-I antigen presentation remains unknown. In this study, we demonstrate that US10 recognizes and binds to all HLA-I (HLA-A, -B, -C, -E, -G) heavy chains. Additionally, impaired recruitment of HLA-I to the peptide loading complex was observed. Notably, the associated effects varied significantly dependending on HLA-I genotype and allotype: (i) HLA-A molecules evaded downregulation by US10, (ii) tapasin-dependent HLA-B molecules showed impaired maturation and cell surface expression, and (iii) β2m-assembled HLA-C, in particular HLA-C*05:01 and -C*12:03, and HLA-G were strongly retained in complex with US10 in the endoplasmic reticulum. These genotype-specific effects on HLA-I were confirmed through unbiased HLA-I ligandome analyses. Furthermore, in HCMV-infected fibroblasts inhibition of overlapping US10 and US11 transcription had little effect on HLA-A, but induced HLA-B antigen presentation. Thus, the US10-mediated impact on HLA-I results in multiple geno- and allotypic effects in a so far unparalleled and multimodal manner.
DOI:doi:10.7554/eLife.85560
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.7554/eLife.85560
 DOI: https://doi.org/10.7554/eLife.85560
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Antigen Presentation
 Cytomegalovirus
 Gene Expression Regulation
 Genotype
 Histocompatibility Antigens Class I
 Host-Pathogen Interactions
 human
 human cytomegalovirus
 Humans
 immunoevasin
 infectious disease
 MHC class I
 microbiology
 peptide loading complex
 Protein Binding
 tapasin
 US10
 Viral Proteins
 viruses
K10plus-PPN:1917688431
Verknüpfungen:→ Zeitschrift

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