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| Verfasst von: | Gorodezki, David [VerfasserIn]  |
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| | Chiang, Jason [VerfasserIn] |
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| | Viaene, Angela N. [VerfasserIn] |
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| | Sievers, Philipp [VerfasserIn] |
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| | Schmid, Simone [VerfasserIn] |
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| | Holzer, Ursula [VerfasserIn] |
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| | Paulsen, Frank [VerfasserIn] |
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| | Schuhmann, Martin U. [VerfasserIn] |
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| | Witt, Olaf [VerfasserIn] |
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| | Schittenhelm, Jens [VerfasserIn] |
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| | Ebinger, Martin [VerfasserIn] |
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| Titel: | A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity |
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| Verf.angabe: | David Gorodezki, Jason Chiang, Angela N. Viaene, Philipp Sievers, Simone Schmid, Ursula Holzer, Frank Paulsen, Martin U. Schuhmann, Olaf Witt, Jens Schittenhelm and Martin Ebinger |
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| E-Jahr: | 2024 |
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| Jahr: | 21 June 2024 |
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| Umfang: | 10 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 20.02.2025 |
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| Titel Quelle: | Enthalten in: Acta Neuropathologica Communications |
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| Ort Quelle: | London : Biomed Central, 2013 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 12(2024) vom: Juni, Artikel-ID 101, Seite 1-10 |
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| ISSN Quelle: | 2051-5960 |
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| Abstract: | Within the past decade, incremental integration of molecular characteristics into the classification of central nervous system neoplasms increasingly facilitated precise diagnosis and advanced stratification, beyond potentially providing the foundation for advanced targeted therapies. We report a series of three cases of infant-type hemispheric glioma (IHG) involving three infants diagnosed with neuroepithelial tumors of the cerebral hemispheres harboring a novel, recurrent TRIM24::MET fusion. Histopathology showed glial tumors with either low-grade or high-grade characteristics, while molecular characterization found an additional homozygous CDKN2A/B deletion in two cases. Two patients showed leptomeningeal dissemination, while multiple supra- and infratentorial tumor manifestations were found in one case. Following subtotal resection (two cases) and biopsy (one case), treatment intensity of adjuvant chemotherapy regimens did not reflect in the progression patterns within the reported cases. Two patients showed progression after first-line treatment, of which one patient died not responding to tyrosine kinase inhibitor cabozantinib. As the detection of a recurrent TRIM24::MET fusion expands the spectrum of renowned driving fusion genes in IHG, this comparative illustration may indicate a distinct clinico-pathological heterogeneity of tumors bearing this driver alteration. Upfront clinical trials of IHG promoting further characterization and the implementation of individualized therapies involving receptor tyrosine kinase inhibition are required. |
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| DOI: | doi:10.1186/s40478-024-01817-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s40478-024-01817-9 |
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| | DOI: https://doi.org/10.1186/s40478-024-01817-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Brain Neoplasms |
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| | Carrier Proteins |
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| | Female |
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| | Glioma |
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| | Humans |
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| | Infant |
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| | Infant-type hemispheric glioma |
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| | Male |
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| | MET fusion |
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| | Oncogene Proteins, Fusion |
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| | Proto-Oncogene Proteins c-met |
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| | TRIM24::MET fusion |
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| K10plus-PPN: | 1917691955 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity / Gorodezki, David [VerfasserIn]; 21 June 2024 (Online-Ressource)
