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| Verfasst von: | Drexler, Richard [VerfasserIn]  |
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| | Khatri, Robin [VerfasserIn] |
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| | Sauvigny, Thomas [VerfasserIn] |
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| | Mohme, Malte [VerfasserIn] |
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| | Maire, Cecile L. [VerfasserIn] |
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| | Ryba, Alice [VerfasserIn] |
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| | Zghaibeh, Yahya [VerfasserIn] |
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| | Dührsen, Lasse [VerfasserIn] |
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| | Salviano-Silva, Amanda [VerfasserIn] |
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| | Lamszus, Katrin [VerfasserIn] |
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| | Westphal, Manfred [VerfasserIn] |
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| | Gempt, Jens [VerfasserIn] |
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| | Wefers, Annika K. [VerfasserIn] |
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| | Neumann, Julia [VerfasserIn] |
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| | Bode, Helena [VerfasserIn] |
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| | Hausmann, Fabian [VerfasserIn] |
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| | Huber, Tobias [VerfasserIn] |
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| | Bonn, Stefan [VerfasserIn] |
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| | Jütten, Kerstin [VerfasserIn] |
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| | Delev, Daniel [VerfasserIn] |
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| | Weber, Katharina J. [VerfasserIn] |
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| | Harter, Patrick N. [VerfasserIn] |
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| | Onken, Julia [VerfasserIn] |
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| | Vajkoczy, Peter [VerfasserIn] |
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| | Capper, David [VerfasserIn] |
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| | Wiestler, Benedikt [VerfasserIn] |
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| | Weller, Michael [VerfasserIn] |
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| | Snijder, Berend [VerfasserIn] |
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| | Buck, Alicia [VerfasserIn] |
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| | Weiss, Tobias [VerfasserIn] |
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| | Göller, Pauline C. [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| | Menstel, Joelle Aline [VerfasserIn] |
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| | Zimmer, David Niklas [VerfasserIn] |
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| | Keough, Michael B. [VerfasserIn] |
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| | Ni, Lijun [VerfasserIn] |
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| | Monje, Michelle [VerfasserIn] |
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| | Silverbush, Dana [VerfasserIn] |
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| | Hovestadt, Volker [VerfasserIn] |
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| | Suvà, Mario L. [VerfasserIn] |
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| | Krishna, Saritha [VerfasserIn] |
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| | Hervey-Jumper, Shawn L. [VerfasserIn] |
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| | Schüller, Ulrich [VerfasserIn] |
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| | Heiland, Dieter H. [VerfasserIn] |
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| | Hänzelmann, Sonja [VerfasserIn] |
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| | Ricklefs, Franz Lennard [VerfasserIn] |
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| Titel: | A prognostic neural epigenetic signature in high-grade glioma |
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| Verf.angabe: | Richard Drexler, Robin Khatri, Thomas Sauvigny, Malte Mohme, Cecile L. Maire, Alice Ryba, Yahya Zghaibeh, Lasse Dührsen, Amanda Salviano-Silva, Katrin Lamszus, Manfred Westphal, Jens Gempt, Annika K. Wefers, Julia E. Neumann, Helena Bode, Fabian Hausmann, Tobias B. Huber, Stefan Bonn, Kerstin Jütten, Daniel Delev, Katharina J. Weber, Patrick N. Harter, Julia Onken, Peter Vajkoczy, David Capper, Benedikt Wiestler, Michael Weller, Berend Snijder, Alicia Buck, Tobias Weiss, Pauline C. Göller, Felix Sahm, Joelle Aline Menstel, David Niklas Zimmer, Michael B. Keough, Lijun Ni, Michelle Monje, Dana Silverbush, Volker Hovestadt, Mario L. Suvà, Saritha Krishna, Shawn L. Hervey-Jumper, Ulrich Schüller, Dieter H. Heiland, Sonja Hänzelmann, Franz L. Ricklefs |
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| E-Jahr: | 2024 |
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| Jahr: | June 2024 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen, Diagramme |
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| Fussnoten: | Online veröffentlicht: 17. Mai 2024 ; Gesehen am 21.02.2025 |
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| Titel Quelle: | Enthalten in: Nature medicine |
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| Ort Quelle: | [New York, NY] : Springer Nature, 1995 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 30(2024), 6 vom: Juni, Seite 1622-1635 |
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| ISSN Quelle: | 1546-170X |
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| Abstract: | Neural-tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is limited. We present an epigenetically defined neural signature of glioblastoma that independently predicts patients’ survival. We use reference signatures of neural cells to deconvolve tumor DNA and classify samples into low- or high-neural tumors. High-neural glioblastomas exhibit hypomethylated CpG sites and upregulation of genes associated with synaptic integration. Single-cell transcriptomic analysis reveals a high abundance of malignant stemcell-like cells in high-neural glioblastoma, primarily of the neural lineage. These cells are further classified as neural-progenitor-cell-like, astrocyte-like and oligodendrocyte-progenitor-like, alongside oligodendrocytes and excitatory neurons. In line with these findings, high-neural glioblastoma cells engender neuron-to-glioma synapse formation in vitro and in vivo and show an unfavorable survival after xenografting. In patients, a high-neural signature is associated with decreased overall and progression-free survival. High-neural tumors also exhibit increased functional connectivity in magnetencephalography and resting-state magnet resonance imaging and can be detected via DNA analytes and brain-derived neurotrophic factor in patients’ plasma. The prognostic importance of the neural signature was further validated in patients diagnosed with diffuse midline glioma. Our study presents an epigenetically defined malignant neural signature in high-grade gliomas that is prognostically relevant. High-neural gliomas likely require a maximized surgical resection approach for improved outcomes. |
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| DOI: | doi:10.1038/s41591-024-02969-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41591-024-02969-w |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41591-024-02969-w |
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| | DOI: https://doi.org/10.1038/s41591-024-02969-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CNS cancer |
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| | DNA methylation |
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| | Translational research |
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| K10plus-PPN: | 191775583X |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ prognostic neural epigenetic signature in high-grade glioma / Drexler, Richard [VerfasserIn]; June 2024 (Online-Ressource)
