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Verfasst von:Egenlauf, Benjamin [VerfasserIn]   i
 Weinstock, K. F. [VerfasserIn]   i
 Marra, A. M. [VerfasserIn]   i
 Eichstaedt, Christina [VerfasserIn]   i
 Harutyunova, Satenik [VerfasserIn]   i
 Grünig, Ekkehard [VerfasserIn]   i
 Xanthouli, Panagiota [VerfasserIn]   i
 Benjamin, Nicola [VerfasserIn]   i
Titel:Association between right heart size and right ventricular output reserve in patients with pulmonary arterial hypertension
Verf.angabe:B. Egenlauf, K.F. Weinstock, A.M. Marra, C.A. Eichstaedt, S. Harutyunova, E. Grünig, P. Xanthouli, N. Benjamin
E-Jahr:2024
Jahr:1 December 2024
Umfang:8 S.
Illustrationen:Illustrationen
Fussnoten:Online verfügbar 17 August 2024, Version des Artikels 30 August 2024 ; Gesehen am 21.02.2025
Titel Quelle:Enthalten in: International journal of cardiology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1981
Jahr Quelle:2024
Band/Heft Quelle:416(2024) vom: Dez., Artikel-ID 132466, Seite 1-8
ISSN Quelle:1874-1754
Abstract:Objectives - Right ventricular (RV) output reserve, defined as increase of cardiac output during exercise, is reduced in patients with pulmonary arterial hypertension (PAH). Aim of this study was to evaluate the association of right heart size measured by echocardiography and invasively measured RV function at rest and during exercise in PAH patients. - Methods - Adult PAH-patients who received routine haemodynamic assessment at rest and during exercise by right heart catheterisation and echocardiographic measurement of right heart size (right atrial (RA) and RV area) were included in this study. Clinical, echocardiographic, laboratory, exercise and invasive haemodynamic parameters were retrospectively analysed. The primary endpoint was to assess the association between right heart size and right ventricular function. - Results - Data from 215 PAH patients (age 58.9 ± 15.9 years, 63.3% female, 62.2% double or triple combination treatment) were analysed in this cross-sectional study. Cardiac index was significantly lower for patients with enlarged RA-area > 18 cm2 at rest, and at 25 and 50 W (all p < 0.001) and for patients with enlarged RV area > 20 cm2 at rest, 25, 50 and 75 W (all p < 0.001). Furthermore, pulmonary vascular resistance and mPAP/CO slope (all p < 0.001) were significantly higher and pulmonary arterial compliance (all p < 0.05) was significantly lower in patients with enlarged RA or RV area. RA and RV area correlated with TAPSE/sPAP (both p < 0.001, R − 0.570 and − 0.530). - Conclusion - This study could underline that an enlargement of RA- and RV-area is associated with an impaired RV function at rest and during exercise in patients with PAH.
DOI:doi:10.1016/j.ijcard.2024.132466
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.ijcard.2024.132466
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S016752732401088X
 DOI: https://doi.org/10.1016/j.ijcard.2024.132466
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Pulmonary arterial hypertension
 Right heart size
 Right ventricular output reserve
K10plus-PPN:1917760876
Verknüpfungen:→ Zeitschrift

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