Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Fritz, Peter [VerfasserIn]   i
 Berns, Christiane [VerfasserIn]   i
 Anton, Hans-Werner [VerfasserIn]   i
 Hensley, Frank W. [VerfasserIn]   i
 Assmann, Jörg [VerfasserIn]   i
 Flentje, Michael [VerfasserIn]   i
 Fournier, Dietrich von [VerfasserIn]   i
 Wannenmacher, Michael [VerfasserIn]   i
Titel:PDR brachytherapy with flexible implants for interstitial boost after breast-conserving surgery and external beam radiation therapy
Verf.angabe:Peter Fritz, Christiane Berns, Hans-Werner Anton, Frank Hensley, Jörg Assmann, Michael Flentje, Dietrich von Fournier, Michael Wannenmacher
E-Jahr:1997
Jahr:October 1997
Umfang:10 S.
Fussnoten:Elektronische Reproduktion der Druck-Ausgabe 5. Januar 1998 ; Gesehen am 24.02.2025
Titel Quelle:Enthalten in: Radiotherapy and oncology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1983
Jahr Quelle:1997
Band/Heft Quelle:45(1997), 1, Seite 23-32
ISSN Quelle:1879-0887
Abstract:Background and purpose: For radiobiological reasons the new concept of pulsed dose rate (PDR) brachytherapy seems to be suitable to replace traditional CLDR brachytherapy with line sources. PDR brachytherapy using a stepping source seems to be particularly suitable for the interstitial boost of breast carcinoma after breast-conserving surgery and external beam irradiation since in these cases the exact adjustment of the active lengths is essential in order to prevent unwanted skin dose and consequential unfavorable cosmetic results. The purpose of this study was to assess the feasibility and morbidity of a PDR boost with flexible breast implants. Materials and methods: Sixty-five high risk patients were treated with an interstitial PDR boost. The criteria for an interstitial boost were positive margin or close margin, extensive intraductal component (EIC), intralymphatic extension, lobular carcinoma, T2 tumors and high nuclear grade (GIII). Dose calculation and specification were performed following the rules of the Paris system. The dose per pulse was 1 Gy. The pulse pauses were kept constant at 1 h. A geometrically optimized dose distribution was used for all patients. The treatment schedule was 50 Gy external beam to the whole breast and 20 Gy boost. PDR irradiations were carried out with a nominal 37 GBq 192-Ir source. Results: The median follow-up was 30 months (minimum 12 months, maximum 54 months). Sixty percent of the patients judged their cosmetic result as excellent, 27% judged it as good, 11% judged it as fair and 2% judged it as poor. Eighty-six percent of the patients had no radiogenous skin changes in the boost area. In 11% of patients minimal punctiform telangiectasia appeared at single puncture sites. In 3% (265) of patients planar telangiectasia appeared on the medial side of the implant. The rate of isolated local recurrences was 1.5%. In most cases geometrical volume optimization (GVO) yields improved dose distributions with respect to homogeneity and compensation of underdosage at the margins of the implant. Only in 9% of patients was the dose distribution impaired by GVO. However, GVO causes a number of substantial changes of the dose distribution which have consequences for its application. Conclusions: The interstitial CLDR boost of the breast can be replaced by the PDR technique without severe acute and late complications and without deterioration of the cosmetic results.
DOI:doi:10.1016/S0167-8140(97)00145-X
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/S0167-8140(97)00145-X
 Volltext: https://www.sciencedirect.com/science/article/pii/S016781409700145X
 DOI: https://doi.org/10.1016/S0167-8140(97)00145-X
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Brachytherapy
 Breast cancer
 Interstitial boost
 Pulsed dose rate
K10plus-PPN:1917906269
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69307509   QR-Code
zum Seitenanfang