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Verfasst von:Zülke, Andrea [VerfasserIn]   i
 Pabst, Alexander [VerfasserIn]   i
 Luppa, Melanie [VerfasserIn]   i
 Oey, Anke [VerfasserIn]   i
 Weise, Solveig [VerfasserIn]   i
 Fankhänel, Thomas [VerfasserIn]   i
 Kosilek, Robert Philipp [VerfasserIn]   i
 Schillok, Hannah [VerfasserIn]   i
 Brettschneider, Christian [VerfasserIn]   i
 Czock, David [VerfasserIn]   i
 Frese, Thomas [VerfasserIn]   i
Titel:Effects of a multidomain intervention against cognitive decline on dementia risk profiles
Titelzusatz:results from the AgeWell.de trial
Verf.angabe:Andrea E. Zülke, Alexander Pabst, Melanie Luppa, Anke Oey, Solveig Weise, Thomas Fankhänel, Robert P. Kosilek, Hannah Schillok, Christian Brettschneider, David Czock, Thomas Frese ... [und weitere]
E-Jahr:2024
Jahr:August 2024
Umfang:1-11$t11
Fussnoten:Zuerst veröffentlicht: 05. Juli 2024
Titel Quelle:Enthalten in: Alzheimer's and dementia
Ort Quelle:Hoboken, NJ : Wiley, 2005
Jahr Quelle:2024
Band/Heft Quelle:20(2024), 8 vom: Aug., Seite 5684-5694
ISSN Quelle:1552-5279
Abstract:INTRODUCTION Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention. METHODS Secondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24-month follow-up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models. RESULTS The intervention reduced LIBRA scores, indicating decreased dementia risk at follow-up (b = -0.63, 95% confidence interval [CI]: -1.14, -0.12). Intervention effects were particularly due to improvements in diet (odds ratio [OR]: 1.60, 95% CI: 1.16, 2.22) and hypertension (OR: 1.61, 95% CI: 1.19, 2.18). DISCUSSION The AgeWell.de intervention reduced dementia risk. However, several risk factors did not improve, possibly requiring more intensive interventions. Highlights The AgeWell.de intervention reduced dementia risk according to LIfestyle for BRAin health (LIBRA) scores. Beneficial effects on LIBRA are mainly due to changes in diet and blood pressure. A pragmatic lifestyle intervention is apt to reduce dementia risk in an at-risk population.
DOI:doi:10.1002/alz.14097
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Resolving-System: https://doi.org/10.1002/alz.14097
 kostenfrei: Resolving-System: https://doi.org/10.25673/117937
 DOI: https://doi.org/10.1002/alz.14097
 DOI: https://doi.org/10.25673/117937
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1899181555
Verknüpfungen:→ Zeitschrift

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