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Status: Bibliographieeintrag

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Verfasst von:Huber, Lena [VerfasserIn]   i
 Knüttel, Manuel Thomas [VerfasserIn]   i
 Kramer, Benedikt [VerfasserIn]   i
 Zaubitzer, Lena [VerfasserIn]   i
 Lammert, Anne [VerfasserIn]   i
 Scherl, Claudia [VerfasserIn]   i
 Rotter, Nicole [VerfasserIn]   i
 Häussler, Daniel [VerfasserIn]   i
Titel:Influence of tyrosine kinase inhibitors and everolimus on TGFβ1 and TGF-β receptor 2 in squamous cell carcinoma cells
Verf.angabe:Lena Huber, Manuel Thomas Knüttel, Benedikt Kramer, Lena Zaubitzer, Anne Lammert, Claudia Scherl, Nicole Rotter and Daniel Häussler
E-Jahr:2024
Jahr:August 2024
Umfang:8 S.
Fussnoten:Online veröffentlicht: 26. Juli 2024 ; Gesehen am 25.02.2025
Titel Quelle:Enthalten in: Anticancer research
Ort Quelle:Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004
Jahr Quelle:2024
Band/Heft Quelle:44(2024), 8 vom: Aug., Seite 3287-3294
ISSN Quelle:1791-7530
Abstract:Background/Aim: Transforming growth factor-β (TGF-β) plays a significant role in the formation of different cancer subtypes. There is evidence that TGF-β pathways promote cancerogenic cell characteristics but also have tumor-suppressor capabilities. The tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib, gefitinib, and everolimus are approved as targeted therapies for several tumor entities, including head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the effects of these substances on the expression levels of TGFβ1 and TGF-β receptor type 2 (TGFβR2) in HPV-negative and HPV-positive SCC cell cultures. Materials and Methods: Expression patterns of TGFβ1 and TGFβR2 were determined using enzyme-linked immunosorbent assay (ELISA) in three HNSCC cell lines (i.e., HNSCC-11A, HNSCC-14C, and CERV196). These cells were incubated with nilotinib, dasatinib, erlotinib, gefitinib, and everolimus (20 μmol/l) and compared to a chemonaive control. An assessment of concentration levels was conducted after 24, 48, 72, and 96 h of treatment. Results: Statistically significant changes in the expression levels of TGFβ1 and TGFβR2 were found in all tested cell cultures (p<0.05) compared to the negative control. An increase in TGFβ-R2 expression was detected after treatment with most of the tested tyrosine kinase inhibitors, whereas a reduction in TGFβ1 was observed. The addition of everolimus had the opposite effect on both TGFβR2 and TGF-B1- expression. Conclusion: Expression of TGFβ1 and TGFβR2 was detected in all cultured HNSCC cell lines. Nilotinib, dasatinib, erlotinib, gefitinib, and everolimus had an impact on the expression levels of TGFβ1 and TGFβR2 in vitro.
DOI:doi:10.21873/anticanres.17147
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.21873/anticanres.17147
 kostenfrei: Volltext: https://ar.iiarjournals.org/content/44/8/3287
 DOI: https://doi.org/10.21873/anticanres.17147
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Head and neck squamous cell carcinoma (HNSCC)
 tyrosine kinase inhibitors
K10plus-PPN:1918444145
Verknüpfungen:→ Zeitschrift

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