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| Verfasst von: | Hering, Marvin [VerfasserIn]  |
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| | Madi, Alaa [VerfasserIn] |
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| | Sandhoff, Roger [VerfasserIn] |
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| | Ma, Sicong [VerfasserIn] |
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| | Wu, Jingxia [VerfasserIn] |
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| | Mieg, Alessa [VerfasserIn] |
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| | Richter, Karsten [VerfasserIn] |
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| | Mohr, Kerstin [VerfasserIn] |
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| | Knabe, Nora [VerfasserIn] |
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| | Stichling, Diana [VerfasserIn] |
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| | Poschet, Gernot [VerfasserIn] |
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| | Bestvater, Felix [VerfasserIn] |
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| | Frank, Larissa [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Umansky, Viktor [VerfasserIn] |
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| | Cui, Guoliang [VerfasserIn] |
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| Titel: | Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma |
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| Verf.angabe: | Marvin Hering, Alaa Madi, Roger Sandhoff, Sicong Ma, Jingxia Wu, Alessa Mieg, Karsten Richter, Kerstin Mohr, Nora Knabe, Diana Stichling, Gernot Poschet, Felix Bestvater, Larissa Frank, Jochen Utikal, Viktor Umansky & Guoliang Cui |
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| E-Jahr: | 2024 |
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| Jahr: | 18 July 2024 |
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| Umfang: | 18 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 27.02.2025 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 6067, Seite 1-18 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | After recognizing its ligand lipopolysaccharide, Toll-like receptor 4 (TLR4) recruits adaptor proteins to the cell membrane, thereby initiating downstream signaling and triggering inflammation. Whether this recruitment of adaptor proteins is dependent solely on protein-protein interactions is unknown. Here, we report that the sphingolipid sphinganine physically interacts with the adaptor proteins MyD88 and TIRAP and promotes MyD88 recruitment in macrophages. Myeloid cell-specific deficiency in serine palmitoyltransferase long chain base subunit 2, which encodes the key enzyme catalyzing sphingolipid biosynthesis, decreases the membrane recruitment of MyD88 and inhibits inflammatory responses in in vitro bone marrow-derived macrophage and in vivo sepsis models. In a melanoma mouse model, serine palmitoyltransferase long chain base subunit 2 deficiency decreases anti-tumor myeloid cell responses and increases tumor growth. Therefore, sphinganine biosynthesis is required for the initiation of TLR4 signal transduction and serves as a checkpoint for macrophage pattern recognition in sepsis and melanoma mouse models. |
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| DOI: | doi:10.1038/s41467-024-50341-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-024-50341-w |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-024-50341-w |
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| | DOI: https://doi.org/10.1038/s41467-024-50341-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | NF-kappaB |
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| | Peritoneal macrophages |
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| | Sphingolipids |
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| | Toll-like receptors |
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| K10plus-PPN: | 1918685967 |
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| Verknüpfungen: | → Zeitschrift |
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Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma / Hering, Marvin [VerfasserIn]; 18 July 2024 (Online-Ressource)
