Dynamic remodelling of the endoplasmic reticulum for mitosis

• Verfasst von: Kors, Suzan [VerfasserIn]
• Verfasst von: Schlaitz, Anne-Lore [VerfasserIn]
• Titel: Dynamic remodelling of the endoplasmic reticulum for mitosis
• Verf.angabe: Suzan Kors and Anne-Lore Schlaitz
• E-Jahr: 2024
• Jahr: November 2024
• Umfang: 10 S.
• Illustrationen: Illustrationen
• Fussnoten: Veröffentlicht: 25. November 2024 ; Gesehen am 03.03.2025
• Titel Quelle: Enthalten in: Journal of cell science
• Ort Quelle: Cambridge : Company of Biologists Limited, 1853
• Jahr Quelle: 2024
• Band/Heft Quelle: 137(2024), 22 vom: Nov., Artikel-ID jcs261444, Seite 1-10
• ISSN Quelle: 1477-9137
• DOI: doi:10.1242/jcs.261444
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 191888336X

Abstract

The endoplasmic reticulum (ER) is a dynamic and continuous membrane network with roles in many cellular processes. The importance and maintenance of ER structure and function have been extensively studied in interphase cells, yet recent findings also indicate crucial roles of the ER in mitosis. During mitosis, the ER is remodelled significantly with respect to composition and morphology but persists as a continuous network. The ER interacts with microtubules, actin and intermediate filaments, and concomitant with the mitotic restructuring of all cytoskeletal systems, ER dynamics and distribution change. The ER is a metabolic hub and several examples of altered ER functions during mitosis have been described. However, we lack an overall understanding of the ER metabolic pathways and functions that are active during mitosis. In this Review, we will discuss mitotic changes to the ER at different organizational levels to explore how the mitotic ER, with its distinct properties, might support cell division.